O32212

PR
Gene name
nhaK (yvgP, BSU33420)
Protein name
Sodium, potassium, lithium and rubidium/H(+) antiporter
Names
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU33420
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

421-505 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O32212

Entry ID Method Resolution Chain Position Source
AF-O32212-F1 Predicted AlphaFoldDB

No variants for O32212

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O32212

No associated diseases with O32212

1 regional properties for O32212

Type Name Position InterPro Accession
domain Cation/H+ exchanger 6 - 414 IPR006153

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
potassium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in).
sodium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).

3 GO annotations of biological process

Name Definition
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
regulation of intracellular pH Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
sodium ion import across plasma membrane The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDIFLVVLVL LTIIAISNIV NRFIPFIPVP LIQVALGILA ASFPQGLHFE LNTELFFVLF
70 80 90 100 110 120
IAPLLFNDGK RTPRAELWNL RAPILLLALG LVFATVIVGG YTIHWMIPAI PLAAAFGLAA
130 140 150 160 170 180
ILSPTDVVAV SALSGRVKMP KGILRLLEGE GLMNDASGLV AFKFAIAAAV TGAFSLAQAA
190 200 210 220 230 240
VSFVFISLGG LLCGVVISFL IIRFRLFLRR LGMQDVTMHM LIQILTPFVI YLAAEEIGVS
250 260 270 280 290 300
GILAVVAGGI THAVEQDRLE STMIKLQIVS SSTWNIILFI LNGLVFVILG TQIPDVISVI
310 320 330 340 350 360
FNDTAISNMK VIGYILVITF TLMLLRFLWV LFFWNGKWFF NKDQNIYKPG LRSTLLISIS
370 380 390 400 410 420
GVRGAVTLAG SFSIPYFLED GTPFPERNLI LFLAAGVILC TLVIATVVLP ILTEKEEEDE
430 440 450 460 470 480
ERNKKLLTAR RKLIKTALQT IKEDMNETNK TASLAVIAEY NEKMKNLRFQ QYTSSNRIKK
490 500 510 520 530 540
HERKVRAQGV KAEQEALMKM LERGDIPEET ANVLQERFNE LEILYANPFK VGLSKTRLKR
550 560 570 580 590 600
LMYWIFFGEH KKPEMSILNE AGLIRATRVK TAKAAIEYLE KHKTDEHKEV FLSVITFYKQ
610 620 630 640 650 660
LIFRLEHSHH ELKSSAHFEN QKLEVKLKAV QAIRNEIQTL FEEREISRDI SHELRQYIND
VEAAMLEGGE