O32090

PR
Gene name
pncB (yueK, BSU31750)
Protein name
Nicotinate phosphoribosyltransferase
Names
NAPRTase
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU31750
EC number
6.3.4.21: Other carbon--nitrogen ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

433-490 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O32090

Entry ID Method Resolution Chain Position Source
AF-O32090-F1 Predicted AlphaFoldDB

No variants for O32090

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O32090

No associated diseases with O32090

3 regional properties for O32090

Type Name Position InterPro Accession
domain Nicotinate phosphoribosyltransferase, N-terminal domain 13 - 137 IPR040727
domain Nicotinate/nicotinamide phosphoribosyltransferase 160 - 349 IPR041525
domain Nicotinate phosphoribosyltransferase C-terminal domain 362 - 470 IPR041619

Functions

Description
EC Number 6.3.4.21 Other carbon--nitrogen ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
nicotinate phosphoribosyltransferase activity Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

1 GO annotations of biological process

Name Definition
NAD salvage Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLEYGFKDDS LSLHTDLYQI NMAETYWRDG IHEKKAIFEL FFRRLPFENG YAVFAGLEKA
70 80 90 100 110 120
IEYLENFKFT DSDLSYLQDE LGYHEDFIEY LRGLSFTGSL YSMKEGELVF NNEPIMRVEA
130 140 150 160 170 180
PLVEAQLIET ALLNIVNYQT LIATKAARIK GVIGDEVALE FGTRRAHEMD AAMWGARAAL
190 200 210 220 230 240
IGGFSATSNV RAGKRFNIPV SGTHAHALVQ AYRDEYTAFK KYAETHKDCV FLVDTYDTLR
250 260 270 280 290 300
SGMPNAIRVA KEFGDRINFI GIRLDSGDLA YLSKKARKML DEAGFTDAKV IASSDLDEHT
310 320 330 340 350 360
IMNLKAQGAR IDVWGVGTKL ITAYDQPALG AVYKLVAIEE DGKMVDTIKI SSNPEKVTTP
370 380 390 400 410 420
GRKKVYRIIN QSNHHSEGDY IALYDEQVND QKRLRMFHPV HTFISKFVTN FYAKDLHELI
430 440 450 460 470 480
FEKGILCYQN PEISDIQQYV QDNLSLLWEE YKRISKPEEY PVDLSEDCWS NKMQRIHEVK
SRIEEELEEE