O31516

PR
Gene name
yesM (BSU06950)
Protein name
Sensor histidine kinase YesM
Names
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU06950
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

61-184 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O31516

Entry ID Method Resolution Chain Position Source
AF-O31516-F1 Predicted AlphaFoldDB

No variants for O31516

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O31516

No associated diseases with O31516

8 regional properties for O31516

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 474 - 574 IPR003594
domain HAMP domain 310 - 368 IPR003660
domain Signal transduction histidine kinase-related protein, C-terminal 511 - 525 IPR004358-1
domain Signal transduction histidine kinase-related protein, C-terminal 531 - 549 IPR004358-2
domain Signal transduction histidine kinase-related protein, C-terminal 558 - 571 IPR004358-3
domain Histidine kinase domain 479 - 574 IPR005467
domain Signal transduction histidine kinase, internal region 381 - 459 IPR010559
domain Double Cache domain 1 46 - 271 IPR033479

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKRVAGWYR RMKIKDKLFV FLSLIMAVSF LFVYSGVQYA FHVYDEQIYR KSSEVLRMSS
70 80 90 100 110 120
ERIEDELKKI EDVSYEIITD EQIQRILSMQ NRDDTYDQYQ MKQELWDQLA GYASDEKYID
130 140 150 160 170 180
SIHVIDARGS EYSAGSSSSD LLQQEQEEVF KRAKAKSGRN LWMTLGGSDP VLISARQIRS
190 200 210 220 230 240
YHQLSLNGLG MVLIQVNVKQ MIRDVPKDWG DSVGDIMIAD QGGNLVYTAH ASAHVPEAAK
250 260 270 280 290 300
ETLKHPGYDL IKKNGKRYFI SYLQSSYQNW SYYNVIPFDQ MFAKISFMKT VIGTCFLLFF
310 320 330 340 350 360
CVVLLFGRKI ANSITEPIEQ LVTAMKSVQH SGIEAGVSLS LPEHTQDEAG MLNRHFTVMM
370 380 390 400 410 420
KRINELMEEN VEKQLIIKET ELKALQAQIN PHFLYNTLES INWLAKANQQ KQISKMVESL
430 440 450 460 470 480
GFLLRNSIHM KKDIVTIQEE ADIVRHYMTI QRFRFEERLK FTLDIDDEVK HCLIPKLTLQ
490 500 510 520 530 540
PLAENAIQYA LEPFTRPCAI RIQAKKAKGC VCITVEDNGP GMDGRILEST GGRGIGLWNI
550 560 570
RERISLTFGE PYGLRIHSEH EKGTRIVITI PCRNEVV