O30807

PR
Gene name
dme (R01837, SMc00169)
Protein name
NAD-dependent malic enzyme
Names
NAD-ME
Species
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
KEGG Pathway
sme:SMc00169
EC number
1.1.1.39: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O30807

Entry ID Method Resolution Chain Position Source
AF-O30807-F1 Predicted AlphaFoldDB

No variants for O30807

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O30807

No associated diseases with O30807

5 regional properties for O30807

Type Name Position InterPro Accession
domain Phosphate acetyl/butaryl transferase 442 - 763 IPR002505
domain Malic enzyme, N-terminal domain 31 - 164 IPR012301
domain Malic enzyme, NAD-binding 176 - 413 IPR012302
conserved_site Malic enzyme, conserved site 172 - 188 IPR015884
domain Malic enzyme, NAD-binding domain, bacterial type 176 - 404 IPR045213

Functions

Description
EC Number 1.1.1.39 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
acyltransferase activity Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
malate dehydrogenase (decarboxylating) (NAD+) activity Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+.
metal ion binding Binding to a metal ion.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.

1 GO annotations of biological process

Name Definition
malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNTGDKAKSQ AVPASGDIDQ QALFFHRYPR PGKLEIQPTK PLGNQRDLAL AYSPGVAAPC
70 80 90 100 110 120
LAIKDNPETA ADFTARANLV AVVSNGTAVL GLGNIGPLAS KPVMEGKAVL FKKFAGIDVF
130 140 150 160 170 180
DIEIDAPTVD RMVDVISALE PTFGGINLED IKAPECFEVE RRLREKMEIP VFHDDQHGTA
190 200 210 220 230 240
IIVAAAVLNG LELAGKDIAE AKIVASGAGA AALACLNLLV TLGARRENIW VHDIEGLVYK
250 260 270 280 290 300
GREALMDEWK AVYAQESDNR VLADSIGGAD VFLGLSAAGV LKPELLARMA EKPLIMALAN
310 320 330 340 350 360
PTPEIMPEVA RAARPDAMIC TGRSDFPNQV NNVLCFPHIF RGALDCGART INEEMKMAAV
370 380 390 400 410 420
RAIAGLAREE PSDVAARAYS GETPVFGPDY LIPSPFDQRL ILRIAPAVAK AAAESGVATR
430 440 450 460 470 480
PIQDFDAYLD KLNRFVFRSG FIMKPVFAAA KNAAKNRVIF AEGEDERVLR AAQVLLEEGT
490 500 510 520 530 540
AKPILIGRPQ IIETRLRRYG LRIRPDVDFE VVNPEGDPRY RDYVDDYFAL VGRLGVIPEA
550 560 570 580 590 600
ARTIVRTNTT VIGALAVKRG EADALICGVE GRYSRHLRDV SQIIGKRSGV LDFSALSLLI
610 620 630 640 650 660
SQRGATFFTD TYVSFSPSAE EIAQTTVMAA NEIRRFGITP RAALVSHSNF GSRDSESAFK
670 680 690 700 710 720
MRTALQLVRE LAPDLEVDGE MHGDSAISEV LRQRVMPDST LNGEANLLVF PNLDAANITL
730 740 750 760
GVVKTMTDSL HVGPILLGSA LPAHILSPSV TSRGVVNMAA LAVVESSHPV