O30245

PR
Gene name
rio2 (AF_2426)
Protein name
RIO-type serine/threonine-protein kinase Rio2
Names
AfRio2
Species
Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
KEGG Pathway
afu:AF_2426
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

11-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for O30245

Entry ID Method Resolution Chain Position Source
1TQI X-ray 200 A A 1-282 PDB
1TQM X-ray 199 A A 1-282 PDB
1TQP X-ray 210 A A 1-282 PDB
1ZAO X-ray 184 A A 1-282 PDB
1ZAR X-ray 175 A A 1-282 PDB
AF-O30245-F1 Predicted AlphaFoldDB

No variants for O30245

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O30245

No associated diseases with O30245

3 regional properties for O30245

Type Name Position InterPro Accession
domain RIO kinase 49 - 281 IPR000687
active_site Tyrosine-protein kinase, active site 214 - 226 IPR008266
domain RIO2 kinase winged helix domain, N-terminal 10 - 86 IPR015285

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNIAELYGKM GKHSWRIMDA IFKNLWDYEY VPLQLISSHA RIGEEKARNI LKYLSDLRVV
70 80 90 100 110 120
QNRQKDYEGS TFTFIGLSLY SLHRLVRSGK VDAIGKLMGE GKESAVFNCY SEKFGECVVK
130 140 150 160 170 180
FHKVGHTSFK KVKEKRDYGD LHFSVLAIRS ARNEFRALQK LQGLAVPKVY AWEGNAVLME
190 200 210 220 230 240
LIDAKELYRV RVENPDEVLD MILEEVAKFY HRGIVHGDLS QYNVLVSEEG IWIIDFPQSV
250 260 270 280
EVGEEGWREI LERDVRNIIT YFSRTYRTEK DINSAIDRIL QE