O29720

PR
Gene name
gyrB
Protein name
DNA gyrase subunit B
Names
Species
Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
KEGG Pathway
afu:AF_0530
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-112 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O29720

Entry ID Method Resolution Chain Position Source
AF-O29720-F1 Predicted AlphaFoldDB

No variants for O29720

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O29720

No associated diseases with O29720

5 regional properties for O29720

Type Name Position InterPro Accession
domain DNA gyrase B subunit, C-terminal 563 - 620 IPR002288
domain Histidine kinase/HSP90-like ATPase 35 - 182 IPR003594
domain TOPRIM domain 419 - 533 IPR006171
domain DNA topoisomerase, type IIA, subunit B, domain 2 227 - 392 IPR013506
domain DNA gyrase subunit B, TOPRIM domain 419 - 532 IPR034160

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSPDQTAVEY TAKDIEVLDD LEAVRKRPGM YIGGVGVRGL HHLLWEVVDN AVDEALAGYC
70 80 90 100 110 120
DTIKVSLHKD GSASVEDNGR GIPTEMHELG KSALEIVMTK LHAGGKFSKK VYRVSGGLHG
130 140 150 160 170 180
VGVSVVNALS EWLEVWVKRN GKIYYQKYQR GSRSPEAGHR TEVLGETKEH GTTVRFKPDR
190 200 210 220 230 240
EIFETTEFKY EIVAQRLKEL AYLNRGLKII LFDEREGKEE TFHFEDGIIG LVRSLNRNRK
250 260 270 280 290 300
PLHEPIYIET TKDGVSVEVA IQFTDSDVEN IQAFANNINT SEGGSHVVGF RAGLTRAVNE
310 320 330 340 350 360
YGKKHLKKFE PVTGVDIREG LTAVISVKVP EPQFEGQTKT KLTNSDVKTV VESAVYSGVL
370 380 390 400 410 420
RWLEENPAQA ETLLNKFILN KKAREAAKRA KELVKRKNEL ITTLPGKLAD CSSKNPEERE
430 440 450 460 470 480
LFIVEGESAG GSAKQARDRR FQAILPIKGK IINVEKAGMA RVLKNDEIKA IISAIGAGIG
490 500 510 520 530 540
KDFDITKARY RRIIIMTDAD VDGAHIRTLL LTFFYRYMRP LIESGYLYIA QPPLYQIKKG
550 560 570 580 590 600
KKSYYAYSDE ELKRTLEQVG GGEVQRYKGL GEMNPQQLWE TTMNPENRIL IQVTLEDAKR
610 620 630
ADELFSILMG EDVESRRNFI MAHSKEVKNL DI