O29633
Gene name |
srp54 |
Protein name |
Signal recognition particle 54 kDa protein |
Names |
SRP54 |
Species |
Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) |
KEGG Pathway |
afu:AF_0622 |
EC number |
3.6.5.4: Acting on GTP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for O29633
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2JQE | NMR | - | A | 313-425 | PDB |
| AF-O29633-F1 | Predicted | AlphaFoldDB |
No variants for O29633
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O29633 | |||||
No associated diseases with O29633
5 regional properties for O29633
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Glutathione S-transferase, N-terminal | 9 - 87 | IPR004045 |
| domain | Glutathione S-transferase, C-terminal | 102 - 194 | IPR004046 |
| domain | Glutathione S-transferase, C-terminal-like | 92 - 209 | IPR010987 |
| domain | Stringent starvation protein A, N-terminal | 11 - 83 | IPR034341 |
| domain | Stringent starvation protein A, C-terminal | 93 - 200 | IPR034342 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.5.4 | Acting on GTP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| signal recognition particle | A complex of protein and RNA which facilitates translocation of proteins across membranes. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 7S RNA binding | Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP). |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| SRP-dependent cotranslational protein targeting to membrane | The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALESLKEVA | RKIAGSSSID | KKFVEEMVKE | IQRALIKADV | NVRQVKEISD | AIKKRALSED |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLPALNAKEQ | ILKIVYEELL | RGVGEGLEIP | LKKAKIMLVG | LQGSGKTTTT | AKMAKYFKDR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GMKVAVVAAD | TWRPAAYEQL | RQLAEEYGIT | FYGEKGEKDA | VKIVKNALEK | LKDHDMIIID |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TAGRHALEDE | LIDEMIKIAE | VARPDYKLLV | LDAAIGQLAS | KQAQAFHEAI | GINGIIITKF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DGTAKGGGAL | SAARQIGIPI | AFIGTGEKVE | DFERFDPAGF | VSRLLGMGDI | KALMEKIERI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ASEEELDPEA | FLKGTFTLKD | IYKQIEAMNK | MGPVRKIFEM | LPFGLGLKVD | NDVMEMTQEK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MKKFRVIMDS | MTEEELLNPK | IIDSSRIRRI | AIGSGTSPQE | VKELLNYYKT | MKNLMKKMKK |
| 430 | |||||
| NKLPIKGLGK | LGF |