O28631

PR
Gene name
hisS (AF_1642)
Protein name
Histidine--tRNA ligase
Names
Histidyl-tRNA synthetase, HisRS
Species
Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
KEGG Pathway
afu:AF_1642
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O28631

Entry ID Method Resolution Chain Position Source
AF-O28631-F1 Predicted AlphaFoldDB

No variants for O28631

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O28631

No associated diseases with O28631

4 regional properties for O28631

Type Name Position InterPro Accession
domain Anticodon-binding 323 - 409 IPR004154
domain Aminoacyl-tRNA synthetase, class II 7 - 309 IPR006195
domain Histidyl-anticodon-binding 319 - 409 IPR033656
domain Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain 8 - 313 IPR041715

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

2 GO annotations of biological process

Name Definition
histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKIERPRGTR DFLPDEMERR REIEKRMRKI AESFGYREVA TPTFEYLELF TRKSGEGIIE
70 80 90 100 110 120
EMYVFKDKSG RDLALRPELT APVMRMFVNE CSVMPKPLRF YYFANCFRYE RPQKGRYREF
130 140 150 160 170 180
WQFGVELIGS ESYLADAEVI ILADKILKDV GVNFSLEIGH VGIMRHLLKP IGEDRASKVM
190 200 210 220 230 240
RLIDKGDREG LESYLAEIRV NEDLRDKIFS LLELKGDESV IEEAKEIIDY DFGHLESLSA
250 260 270 280 290 300
LLRDVGVDFT LNLGIARGLD YYTGVVFECY AEGLGAQKQV CGGGSYELSS LFGGPVTPST
310 320 330 340 350 360
GFAIGFDRVC EACSVEAGEK SVVAVVSFKG LESQAFRVAS MLRERGFTAV VDVMGRNLKK
370 380 390 400
QMSFASEMGV KYAVILGPDE VKSGRVAIKN LETQEQVVVA EEELFSILQ