O28552

PR
Gene name
polC (AF_1722)
Protein name
DNA polymerase II large subunit
Names
Pol II, Exodeoxyribonuclease large subunit
Species
Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
KEGG Pathway
afu:AF_1722
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

263-345 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O28552

Entry ID Method Resolution Chain Position Source
AF-O28552-F1 Predicted AlphaFoldDB

No variants for O28552

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O28552

No associated diseases with O28552

7 regional properties for O28552

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 322 - 389 IPR003141
domain PHP domain 323 - 681 IPR004013
domain DNA polymerase III epsilon subunit, exonuclease domain 403 - 604 IPR006054
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 826 - 1097 IPR011708
domain Exonuclease, RNase T/DNA polymerase III 407 - 576 IPR013520
domain DNA polymerase, helix-hairpin-helix motif 1354 - 1436 IPR029460
domain DNA polymerase III alpha subunit finger domain 1101 - 1240 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
exodeoxyribonuclease I activity Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides.

2 GO annotations of biological process

Name Definition
DNA catabolic process, exonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDATLDRFFP LFESESNEDF WRIEEIRRYH ESLMVELDRI YRIAEAARKK GLDPELSVEI
70 80 90 100 110 120
PIAKNMAERV EKLMNLQGLA KRIMELEEGG LSRELICFKV ADEIVEGKFG EMPKEEAIDK
130 140 150 160 170 180
AVRTAVAIMT EGVVAAPIEG IARVRIDREN FLRVYYAGPI RSAGGTAQVI SVLVADYVRR
190 200 210 220 230 240
KAEIGRYVPT EEEILRYCEE IPLYKKVANL QYLPSDEEIR LIVSNCPICI DGEPTESAEV
250 260 270 280 290 300
SGYRNLPRVE TNRVRGGMAL VIAEGIALKA PKLKKMVDEV GIEGWEWLDA LIKGGGDSGS
310 320 330 340 350 360
EEEKAVIKPK DKYLSDIVAG RPVLSHPSRK GGFRLRYGRA RNSGFATVGV NPATMYLLEF
370 380 390 400 410 420
VAVGTQLKVE RPGKAGGVVP VSTIEGPTVR LKNGDVVKIN TLSEAKALKG EVAAILDLGE
430 440 450 460 470 480
ILINYGDFLE NNHPLIPASY TYEWWIQEAE KAGLRGDYRK ISEEEALKLC DEFHVPLHPD
490 500 510 520 530 540
YTYLWHDISV EDYRYLRNFV SDNGKIEGKH GKSVLLLPYD SRVKEILEAL LLEHKVRESF
550 560 570 580 590 600
IVIETWRAFI RCLGLDEKLS KVSEVSGKDV LEIVNGISGI KVRPKALSRI GARMGRPEKA
610 620 630 640 650 660
KERKMSPPPH ILFPVGMAGG NTRDIKNAIN YTKSYNAKKG EIEVEIAIRK CPQCGKETFW
670 680 690 700 710 720
LKCDVCGELT EQLYYCPSCR MKNTSSVCES CGRECEGYMK RKVDLRELYE EAIANLGEYD
730 740 750 760 770 780
SFDTIKGVKG MTSKTKIPER LEKGILRVKH GVFVFKDGTA RFDATDLPIT HFKPAEIGVS
790 800 810 820 830 840
VEKLRELGYE RDYKGAELKN ENQIVELKPQ DVILPKSGAE YLLRVANFID DLLVKFYKME
850 860 870 880 890 900
PFYNAKSVED LIGHLVIGLA PHTSAGVLGR IIGFSDVLAG YAHPYFHAAK RRNCDGDEDC
910 920 930 940 950 960
FMLLLDGLLN FSRKFLPDKR GGQMDAPLVL TAIVDPREVD KEVHNMDIVE RYPLEFYEAT
970 980 990 1000 1010 1020
MRFASPKEME DYVEKVKDRL KDESRFCGLF FTHDTENIAA GVKESAYKSL KTMQDKVYRQ
1030 1040 1050 1060 1070 1080
MELARMIVAV DEHDVAERVI NVHFLPDIIG NLRAFSRQEF RCTRCNTKYR RIPLVGKCLK
1090 1100 1110 1120 1130 1140
CGNKLTLTVH SSSIMKYLEL SKFLCENFNV SSYTKQRLML LEQEIKSMFE NGTEKQVSIS
DFV