O28392

PR
Gene name
rpo2C
Protein name
DNA-directed RNA polymerase subunit Rpo2C
Names
DNA-directed RNA polymerase subunit B'
Species
Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
KEGG Pathway
afu:AF_1887
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

217-351 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O28392

Entry ID Method Resolution Chain Position Source
AF-O28392-F1 Predicted AlphaFoldDB

No variants for O28392

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O28392

No associated diseases with O28392

5 regional properties for O28392

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 137 - 507 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 360 - 372 IPR007121
domain RNA polymerase Rpb2, domain 7 509 - 599 IPR007641
domain RNA polymerase Rpb2, domain 4 6 - 67 IPR007646
domain RNA polymerase Rpb2, domain 5 89 - 120 IPR007647

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRKCRVYING ALVGFHDNGE ELANKIRELR RKGRISNQVN VVYYPDSNEV RINTDAGRAR
70 80 90 100 110 120
RPLIVVKDGK PLVTPEHIEK IKKGELTIED LVRQGLIEYL DAEEEENAYV AVYEHELTPE
130 140 150 160 170 180
HTHLELDPSL IVGICTGSIP YAEHNASPRN TMGAAMIKQS LGIPYSNLAW RTDTRGHLMQ
190 200 210 220 230 240
HPQVPIVTTD TQVEIKFDER PAGQNFVVAV LSYEGYNIED ALIMNKGSVE RGLGRSFFYR
250 260 270 280 290 300
TYESEEMRYP GGQEDKFEIP GADISGFRGA EAYAHLDEDG LIFPETEVGP DDVLIGRTSP
310 320 330 340 350 360
PRFLEEPTEL GISPQKRRET SVTMRSNEKG VVDAVFLMQS EGGSKLAKVR VRDLRIPELG
370 380 390 400 410 420
DKFASRHGQK GVVGLLVPEE DMPFTESGIV PDLIINPHAI PSRMTVGHVL EMIGGKVGSL
430 440 450 460 470 480
EGRRVDGSLF HGESEEDLRA TLKKYGFSHT GKEVMYDGIT GRRYLVDIFV GVIYYQKLYH
490 500 510 520 530 540
MVSSKIHARS RGPVQVLTRQ PTEGRARKGG LRFGEMERDV LIGHGAALLL KDRLLEESDK
550 560 570 580 590 600
VEVWVCGNCG HVATYDYRRN TAYCHICDDE SNIHKVEMSY AFKLLLDELK SMMIAPRIIL
GDKA