O28339

PR
Gene name
purL
Protein name
Phosphoribosylformylglycinamidine synthase subunit PurL
Names
FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II
Species
Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
KEGG Pathway
afu:AF_1940
EC number
6.3.5.3: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

387-456 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O28339

Entry ID Method Resolution Chain Position Source
AF-O28339-F1 Predicted AlphaFoldDB

No variants for O28339

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O28339

No associated diseases with O28339

5 regional properties for O28339

Type Name Position InterPro Accession
domain PurM-like, C-terminal domain 234 - 388 IPR010918-1
domain PurM-like, C-terminal domain 610 - 736 IPR010918-2
domain PurM-like, N-terminal domain 99 - 221 IPR016188-1
domain PurM-like, N-terminal domain 478 - 595 IPR016188-2
domain Phosphoribosylformylglycinamidine synthase, linker domain 24 - 73 IPR041609

Functions

Description
EC Number 6.3.5.3 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phosphoribosylformylglycinamidine synthase activity Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate.

1 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYRKVDVPFE LYEVEILDAS EEELAKISEE MGLALSVDEM KRIQDYFRQK GRNPYDIELQ
70 80 90 100 110 120
SLAQAWSEHC CYKSSKYYLR QYLLEASKAD YVISAIEEDA GVVEFDDEYA YVTAFESHNH
130 140 150 160 170 180
PSAIEPYGGA ATGIGGILRD VLCMGAQPIA LIDPLFFGNL DTPYEKLPRG TKHPLYLLKG
190 200 210 220 230 240
VVAGIRDYGN RVGIPTVAGM VFFDNSYLTN CLVNVGCVGI VRKDRIIHSR AGGAGDLFVL
250 260 270 280 290 300
AGGKTGRDGI HGVTFASAEL DEKSEEEARG AVQLGNPIMK EPLIHACLEV VEKGLLTGMK
310 320 330 340 350 360
DLGGGGLSCV IGEMALAAGF GAEVYLDKVP LKEEGMAPWE IWISESQERM MLTVRPEHID
370 380 390 400 410 420
EVLYIFQKWD VPATVVGKVI PEKITRIYYK GYKIYEMDTE FVTSGPEYCR PYVARKPEKE
430 440 450 460 470 480
LHEEVEPPAD YVKTFMKMLS HPNAAFKEWI VRQYDHEVRA STVLKPLQGK MNFETHGDAA
490 500 510 520 530 540
VIKPTRSFRG LAITADVNPW MCKVDPYWGA ASSFDEMVRN LVAVNAVPHS FNDCLNFGNP
550 560 570 580 590 600
EKPERMGEFV EAVKALGWMA KGVGVPCVSG NVSFYNETPY GAVAPTPSLL GVGIVEDVRK
610 620 630 640 650 660
AITSEFKGRG AVILVGETHN EFGGSLYSAV MGQRCHKVPR TSPERLKTYS DAMLESFRKF
670 680 690 700 710 720
EVKACHDVSM GGLAVCIAEM SFGRGLGFEA ARELSFVELF SESNTRWVVE VPESVAEGYA
730 740 750 760
EFFRAKELKA EVIGYSGGER LDFGAFSVEL GEADKSWREG LTKFL