O28305
Gene name |
hemB (AF_1974) |
Protein name |
Delta-aminolevulinic acid dehydratase |
Names |
ALAD, ALADH, Porphobilinogen synthase |
Species |
Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) |
KEGG Pathway |
afu:AF_1974 |
EC number |
4.2.1.24: Hydro-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O28305
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O28305-F1 | Predicted | AlphaFoldDB |
No variants for O28305
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O28305 | |||||
No associated diseases with O28305
1 regional properties for O28305
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Delta-aminolevulinic acid dehydratase, active site | 241 - 253 | IPR030656 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.2.1.24 | Hydro-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| porphobilinogen synthase activity | Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protoporphyrinogen IX biosynthetic process | The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEFPKVRMR | RLRKANLRWM | FREARLSPEN | LITPIFVDEN | IKEKKPIESM | PDYFRIPLEM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VDKEVEECLE | KDLRSFILFG | IPSYKDETGS | SAYDQNGVIQ | KAVRRIKAEF | PDAVIVTDVC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LCEYTTHGHC | GVVKDGEIVN | DETLPIIGKT | AVSHAESGAD | IVAPSGMMDG | MVKAIREALD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AAGFESTPIM | SYSAKYASNF | YSPFRDAAES | GFKFGDRRGY | QMDIHNAREA | MREIELDVKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GADIIMVKPA | LPYLDIIRMV | RERFDLPLAA | YNVSGEYSMI | KAAIKNGWLS | EEAIYEVLIS |
| 310 | 320 | ||||
| IKRAGADLII | TYHSKEIAEK | LQ |