O28303

PR
Gene name
pan
Protein name
Proteasome-activating nucleotidase
Names
PAN, Proteasomal ATPase, Proteasome regulatory ATPase, Proteasome regulatory particle
Species
Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
KEGG Pathway
afu:AF_1976
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-131 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

10 structures for O28303

Entry ID Method Resolution Chain Position Source
2WG5 X-ray 210 A A/B/C/D/E/F/G/H/I/J/K/L 57-134 PDB
2WG6 X-ray 250 A A/B/C/D/E/F/G/H/I/J/K/L 57-134 PDB
6HE4 EM 485 A H/I/J/K/L/M 123-389 PDB
6HE5 EM 412 A H/I/J/K/L/M 2-398 PDB
6HE8 EM 686 A H/I/J/K/L/M 9-398 PDB
6HE9 EM 635 A H/I/J/K/L/M 9-398 PDB
6HEA EM 704 A H/I/J/K/L/M 9-398 PDB
6HEC EM 695 A H/I/J/K/L/M 9-398 PDB
6HED EM 695 A H/I/J/K/L/M 9-398 PDB
AF-O28303-F1 Predicted AlphaFoldDB

No variants for O28303

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O28303

No associated diseases with O28303

5 regional properties for O28303

Type Name Position InterPro Accession
domain AAA+ ATPase domain 174 - 313 IPR003593
domain ATPase, AAA-type, core 178 - 311 IPR003959
conserved_site ATPase, AAA-type, conserved site 281 - 299 IPR003960
domain Proteasomal ATPase OB C-terminal domain 65 - 120 IPR032501
domain AAA ATPase, AAA+ lid domain 333 - 376 IPR041569

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
proteasome-activating nucleotidase complex A homohexameric complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
proteasome-activating activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

2 GO annotations of biological process

Name Definition
proteasomal protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
protein unfolding The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGDSEIQYLL EKLKKLEEDY YKLRELYRRL EDEKKFIESE RIRYEREVRR LRSEVERLRS
70 80 90 100 110 120
PPLLVGVVSD ILEDGRVVVK SSTGPKFVVN TSQYINEEEL KPGARVALNQ QTLAIVNVLP
130 140 150 160 170 180
TSKDPMVYGF EVEEKPEVSY EDIGGLDVQI EEIREAVELP LLKPELFAEV GIEPPKGVLL
190 200 210 220 230 240
YGPPGTGKTL LAKAVANQTR ATFIRVVGSE FVQKYIGEGA RLVREVFQLA KEKAPSIIFI
250 260 270 280 290 300
DELDAIAARR TNSDTSGDRE VQRTMMQLLA ELDGFDPRGD VKVIGATNRI DILDPAILRP
310 320 330 340 350 360
GRFDRIIEVP LPTFEGRIQI FKIHTRKMKL AEDVDFKELA RITEGASGAD IKAICTEAGM
370 380 390
FAIREERAKV TMLDFTKAIE KVLKKTTPIP DLKGVMFV