AiPD: Autoinhibited Protein Database

Gene name	cca (AF_2156)
Protein name	CCA-adding enzyme
Names	CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT
Species	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
KEGG Pathway	afu:AF_2156
EC number	2.7.7.72: Nucleotidyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-59 (Predicted disordered autoinhibitory region) PR

1-59 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1R89	X-ray	180 A	A	1-437	PDB
1R8A	X-ray	210 A	A	1-437	PDB
1R8B	X-ray	200 A	A	1-437	PDB
1R8C	X-ray	190 A	A	1-437	PDB
1SZ1	X-ray	621 A	A/B	1-437	PDB
1TFW	X-ray	220 A	A/B/C/D	1-437	PDB
1TFY	X-ray	320 A	A/B/C/D	1-437	PDB
1UET	X-ray	200 A	A	1-437	PDB
1UEU	X-ray	200 A	A	1-437	PDB
1UEV	X-ray	270 A	A	1-437	PDB
2DR5	X-ray	280 A	A	1-437	PDB
2DR7	X-ray	280 A	A	1-437	PDB
2DR8	X-ray	250 A	A	1-437	PDB
2DR9	X-ray	280 A	A	1-437	PDB
2DRA	X-ray	250 A	A	1-437	PDB
2DRB	X-ray	280 A	A	1-437	PDB
2DVI	X-ray	261 A	A	1-437	PDB
2ZH1	X-ray	280 A	A	1-437	PDB
2ZH2	X-ray	266 A	A	1-437	PDB
2ZH3	X-ray	250 A	A	1-437	PDB
2ZH4	X-ray	265 A	A	1-437	PDB
2ZH5	X-ray	260 A	A	1-437	PDB
2ZH6	X-ray	250 A	A	1-437	PDB
2ZH7	X-ray	300 A	A	2-437	PDB
2ZH8	X-ray	265 A	A	1-437	PDB
2ZH9	X-ray	290 A	A	1-437	PDB
2ZHA	X-ray	295 A	A	1-437	PDB
2ZHB	X-ray	305 A	A	2-437	PDB
3OUY	X-ray	269 A	A/B	1-437	PDB
3OV7	X-ray	300 A	A/B	1-437	PDB
3OVA	X-ray	198 A	A	3-437	PDB
3OVB	X-ray	195 A	A/B	1-437	PDB
3OVS	X-ray	280 A	A/B	1-437	PDB
4X4N	X-ray	295 A	A/C/E/F	1-437	PDB
4X4O	X-ray	320 A	A/C	1-437	PDB
4X4P	X-ray	300 A	A/C/E/G	1-437	PDB
4X4Q	X-ray	315 A	A/C	1-437	PDB
4X4R	X-ray	320 A	A/C	1-437	PDB
4X4S	X-ray	325 A	A/C	1-437	PDB
4X4T	X-ray	250 A	A/C/E/F	1-437	PDB
4X4U	X-ray	270 A	A/C/E/F	1-437	PDB
4X4V	X-ray	260 A	A/C	1-437	PDB
AF-O28126-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for O28126

Type	Name	Position	InterPro Accession
domain	Polymerase, nucleotidyl transferase domain	27 - 132	IPR002934
domain	2-5OAS/ClassI-CCAase, nucleotidyltransferase domain	38 - 137	IPR006116
domain	tRNA nucleotidyltransferase, substrate binding	146 - 254	IPR015329

		Description
EC Number	2.7.7.72	Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
No GO annotations for cellular component

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity	Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate.
CTP:3'-cytidine-tRNA cytidylyltransferase activity	Catalysis of the reaction: a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate.
CTP:tRNA cytidylyltransferase activity	Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate.
magnesium ion binding	Binding to a magnesium (Mg) ion.
tRNA binding	Binding to a transfer RNA.
tRNA cytidylyltransferase activity	Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1).

Name	Definition
RNA repair	Any process that results in the repair of damaged RNA.
tRNA 3'-terminal CCA addition	Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins