O28041

PR
Gene name
purB (AF_2242)
Protein name
Adenylosuccinate lyase
Names
ASL, Adenylosuccinase, ASase
Species
Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
KEGG Pathway
afu:AF_2242
EC number
4.3.2.2: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

16-89 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O28041

Entry ID Method Resolution Chain Position Source
AF-O28041-F1 Predicted AlphaFoldDB

No variants for O28041

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O28041

No associated diseases with O28041

3 regional properties for O28041

Type Name Position InterPro Accession
domain Adenylosuccinate lyase C-terminal 356 - 436 IPR019468
conserved_site Fumarate lyase, conserved site 268 - 277 IPR020557
domain Fumarate lyase, N-terminal 12 - 293 IPR022761

Functions

Description
EC Number 4.3.2.2 Lyases acting on amides, amidines, etc
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.

2 GO annotations of biological process

Name Definition
'de novo' AMP biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIVHPIDYRY GTPEMKRIWS EDSKIKRMVR VEMALLRALA KKGYLSEEEA KEAKKKAYSV
70 80 90 100 110 120
TPERVKEIEA EIKHDIMALV KAITEATGCR WVHFGATSND IIDTATALQL RDSLKILEVK
130 140 150 160 170 180
IKRLAKVLAD KALEYKDVVC LGRTHGQAAL PTTYGFRFAL WAAEVARHYI RLQQMKDRLL
190 200 210 220 230 240
VGQMSGAVGT QAAFGKDGFE IEEEVMRLLN LKPALISSQI IPRDSYCEYL EFLANLAATL
250 260 270 280 290 300
EKIALNFRLL QRAEVGELME KFEAKQVGSS TMPHKRNPID CENVCGLARV VRGFVEPQHQ
310 320 330 340 350 360
SAILWEERDL TNSSAERITL VESTVLADHI LTKMIKVVSS VSLNLENIRR NLEMQRGLNL
370 380 390 400 410 420
SEAVMIEMTK RGVGRQEAHE ILRQAAMRAY ENNSSLLDEL LKDERVMKYF KEDELREILK
430 440
PENYLGTARE RVERVVRWVN EVLK