O27874

PR
Gene name
glyS
Protein name
Glycine--tRNA ligase
Names
Glycyl-tRNA synthetase, GlyRS
Species
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
KEGG Pathway
mth:MTH_1846
EC number
6.1.1.14: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

334-412 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O27874

Entry ID Method Resolution Chain Position Source
AF-O27874-F1 Predicted AlphaFoldDB

No variants for O27874

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O27874

No associated diseases with O27874

4 regional properties for O27874

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 155 - 242 IPR002314
domain Anticodon-binding 473 - 562 IPR004154
domain Aminoacyl-tRNA synthetase, class II 7 - 466 IPR006195
domain Glycyl-tRNA synthetase-like core domain 10 - 335 IPR033731

Functions

Description
EC Number 6.1.1.14 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glycine-tRNA ligase activity Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

1 GO annotations of biological process

Name Definition
glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MINVNHERTM TVARKRGFLW SSFEIYSGVA GFVDYGPLGA TLKNKIMNRW REFYVVREGF
70 80 90 100 110 120
YEIESPTIMP EEALKASGHV DHFNDPMTQC KECMDVYRAD HIIEDATGRD VEGLENQELT
130 140 150 160 170 180
EIISDEGIRC PRCGGHLTHV WSYNLMFQTL IGARGKKTGY LRPETAQGIF IPFKRLLRFF
190 200 210 220 230 240
RNRLPFGVVQ LGKSYRNEIS PRQGVIRLRE FTQAEAEIFV DPEHKTHPDF EEVKEDILRL
250 260 270 280 290 300
YPAGRQMEES GTVDMTAAEA LEAGVISSEV LTYHLCLAKR FLMDIGIPED ALRFRQHLPS
310 320 330 340 350 360
EMAHYAIDCW DVEAFTDSYG WIEIIGIADR TDYDLRSHSQ HSGEDLRVFI EYDEPRRIRK
370 380 390 400 410 420
RAVKPDMGKL GPKFRKDAAR IASALSEVDV EEIEKALDEE GRFILEGEFE ILPDDVSFED
430 440 450 460 470 480
VEEVVTGRKV YPHVIEPSFG IDRIIYTLLL HSLVDDGERT YFRLPPHVAP VEVTVLPLVN
490 500 510 520 530 540
REEMVMTALE IERNLRRSGF IAEFDSSGTI GRRYARADEI GVPFAVTVDH ETLEDGTVTL
550 560
RNRDDCSQVR VKIEELVPTL EKLRG