O27795

PR
Gene name
tyrS
Protein name
Tyrosine--tRNA ligase
Names
Tyrosyl-tRNA synthetase, TyrRS
Species
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
KEGG Pathway
mth:MTH_1767
EC number
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

174-262 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O27795

Entry ID Method Resolution Chain Position Source
AF-O27795-F1 Predicted AlphaFoldDB

No variants for O27795

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O27795

No associated diseases with O27795

3 regional properties for O27795

Type Name Position InterPro Accession
domain Adenylosuccinate lyase C-terminal 374 - 458 IPR019468
conserved_site Fumarate lyase, conserved site 285 - 294 IPR020557
domain Fumarate lyase, N-terminal 37 - 304 IPR022761

Functions

Description
EC Number 6.1.1.1 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tyrosine-tRNA ligase activity Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDDSLKTITR DVLEVITPEE LMDVLKKDEP VVYTGYEPSG RIHLGHALTV RKLRELQDAG
70 80 90 100 110 120
FRVKILLADY HAYLNGKGSM ERIRELADYN QKCFLALGLS PERTEFILGS SFQTEPEYTD
130 140 150 160 170 180
LVYRLALITT LLRAKRSMAQ ITRESRDHKV AEVIYPLMQV IDMVYLGVDV ALGGMEQRKI
190 200 210 220 230 240
HMLARENLPR LGFDAPVCIH TPLLHGTDGS EKMSSSKGNF IAVDDSPDEI REKVKKSYCP
250 260 270 280 290 300
MGETEGNPII EIVKYFIMPE YGMMTIRRPE KFGGDLELEL DELLEMYSSS ELHPLDLKNA
310
VSDYLVDMLE PVREYMEGV