O27661

PR
Gene name
topA
Protein name
DNA topoisomerase 1
Names
DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme
Species
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
KEGG Pathway
mth:MTH_1624
EC number
5.6.2.1: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

323-412 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O27661

Entry ID Method Resolution Chain Position Source
AF-O27661-F1 Predicted AlphaFoldDB

No variants for O27661

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O27661

No associated diseases with O27661

8 regional properties for O27661

Type Name Position InterPro Accession
domain DNA topoisomerase, type IA, domain 2 137 - 231 IPR003601
domain DNA topoisomerase, type IA, DNA-binding domain 273 - 523 IPR003602
domain TOPRIM domain 9 - 151 IPR006171
domain DNA topoisomerase, type IA, central 108 - 121 IPR013497-1
domain DNA topoisomerase, type IA, central 162 - 571 IPR013497-2
domain DNA topoisomerase, type IA, zn finger 595 - 634 IPR013498-1
domain DNA topoisomerase, type IA, zn finger 677 - 713 IPR013498-2
active_site DNA topoisomerase, type IA, active site 310 - 324 IPR023406

Functions

Description
EC Number 5.6.2.1 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type I (single strand cut, ATP-independent) activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRSLSGKMHE VIICEKPKSS EKIAGALFPD AMKKKHGKVS YWEHVEGDKR VTIVSAVGHL
70 80 90 100 110 120
YSLRPRQSNE EHFFDLEWAP IHEIDKKKGY VKDYLNVIRK FAAGADRYIH ACDYDIEGTL
130 140 150 160 170 180
IGFNALKYGC GEEALRKTSR MKFSTLTREE IQRAYKNPIE VDYGQVDSGA ARHILDFIFG
190 200 210 220 230 240
VNISRSLMKS VKAATNRFIK LSAGRVQTPT LAILVEREKE IRDFKPVPYW IIRAELGEGI
250 260 270 280 290 300
IAESKRGKIF KRELVDSILE KCQGSDAEVK DVRVRDTIRK PPVPFDLGTL QSEAYRVFGF
310 320 330 340 350 360
SPKKTQTIAQ NLYTEGYTSY PRTSSQKLPE SIGYEKILKN LAKNPRFGVH IERLRGPLKP
370 380 390 400 410 420
HEGKKEDDAH PAIHPTGLLP SELSKDEKKV YDLIVHRFIS VFGEDAILQT MKVELEIGEE
430 440 450 460 470 480
EFSFSRKRVS KAGWMESYPY TKMEDEEFPE ISGGDSLAVR SVSADERETK PPARYNEASL
490 500 510 520 530 540
IRELERRGLG TKSTRADIIA KLYDRKYIEG KKIRVSPLGE NIIDTLTRYC EKIISEELTR
550 560 570 580 590 600
QFERELEDIM RGKISKDRVI DEAITEVRSI LSDIEENLRD IGKELYRAYQ DSRVVGECPA
610 620 630 640 650 660
CGGKLVIKYS PRNRSTFVGC SSYPDCRTVY SLPRGASVLK SLCEKCGLPM ISYGRPRQRA
670 680 690 700 710
CLDPKCGKKK SEVEEVVGKC PECGSDLIKR SGRYGEFVGC KGFPKCRFTC SVDEVPEG