O27580

PR
Gene name
purB (MTH_1537)
Protein name
Adenylosuccinate lyase
Names
ASL, Adenylosuccinase, ASase
Species
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
KEGG Pathway
mth:MTH_1537
EC number
4.3.2.2: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

34-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O27580

Entry ID Method Resolution Chain Position Source
AF-O27580-F1 Predicted AlphaFoldDB

No variants for O27580

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O27580

No associated diseases with O27580

3 regional properties for O27580

Type Name Position InterPro Accession
domain Adenylosuccinate lyase C-terminal 362 - 442 IPR019468
conserved_site Fumarate lyase, conserved site 274 - 283 IPR020557
domain Fumarate lyase, N-terminal 11 - 297 IPR022761

Functions

Description
EC Number 4.3.2.2 Lyases acting on amides, amidines, etc
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.

2 GO annotations of biological process

Name Definition
'de novo' AMP biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAIHPVEFRY GTPEMRVIWE AENKLQKMLD VEAALAQAEG ELGIIPAEAA SEIVRKASTE
70 80 90 100 110 120
FVTLERVNEI ERDTKHDIAS LVKALAEQCE GDAGEYVHFG ATSNDIVDTS NSLLLRDSIS
130 140 150 160 170 180
VLRDKLTRVL EVLLALADEN RDRVCIGRTH GQHALPTTYG MKFAIWADEI HRQLERLDAC
190 200 210 220 230 240
SERLCVGMMT GAVGTTAALG EEGLEVHERV SEILGLRPVL ISNQVVQRDN HAEFIMVLAN
250 260 270 280 290 300
IATTLDKIAL EIRNLQRTEI MEVGEKFDPE KQVGSSTMPH KMNPITAERI CGIARVIRSY
310 320 330 340 350 360
VVAALENNPL WHERDLTNSS SERIILPEAC ILTDYILKLT LDVLCNLVFY PENIKRNLEF
370 380 390 400 410 420
TGGLIMAERL MAELTRRGMG RQTAYAAVRQ CAIEASRTGR SLRDVVLERS EIMDYLTVED
430 440
LEEIMNPETY IGSARRMVER VLEESQKWL