O27509
Gene name |
cbiA |
Protein name |
Cobyrinate a,c-diamide synthase |
Names |
Cobyrinic acid a,c-diamide synthetase, Ni-sirohydrochlorin a,c-diamide synthase, Ni-sirohydrochlorin a,c-diamide synthetase |
Species |
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) |
KEGG Pathway |
mth:MTH_1460 |
EC number |
6.3.5.11: Carbon--nitrogen ligases with glutamine as amido-N-donor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O27509
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O27509-F1 | Predicted | AlphaFoldDB |
No variants for O27509
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O27509 | |||||
No associated diseases with O27509
1 regional properties for O27509
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ciliogenesis-associated TTC17-interacting protein, dimerization/docking domain | 306 - 345 | IPR047501 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.5.11 | Carbon--nitrogen ligases with glutamine as amido-N-donor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cobyrinic acid a,c-diamide synthase activity | Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cobalamin biosynthetic process | The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. |
| glutamine metabolic process | The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. |
| methanogenesis | The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRVVLAGTGS | AVGKTTIATG | IMKALSGRGV | QPFKVGPDYI | DPSYHTMATG | NTSRNIDSFF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MTEAQIREAF | TRAMKLSGSR | MGIIEGVRGL | YEGISPIGDT | GSTASVAKAL | DAPVVLIINS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RSLVKSAAAM | VLGFRSLDRE | VKIEGVILNQ | VKNRRHYLKT | RRAVEELTGT | AVIGGIPRSS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ELEVEQRHLG | LVPAVERDTI | AAQIEKWGLA | MEEYIDLEAL | QDIMSSAGKI | RGERQPLWQR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GNRKRVRIGV | AIDEAFNFYY | QENIEALEDN | AASVVPFSPI | HDEELPDVDA | VYIGGGYPEI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FAAELESNTS | MRKSIQRFHA | DGRPIFGECG | GLMYLMSSID | EREMCGVFPH | PAEMTGRVQG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSYVIAEAVM | DNLITEAGDK | FRGHEFHYSR | VLGASGGKFA | FRVLRGRGIV | DSLDGITSGS |
| 430 | 440 | ||||
| SLASYIHIHA | ASCPQFAANF | TRNAWEF |