O27438
Gene name |
rpa (MTH_1384/MTH_1385) |
Protein name |
Replication factor A |
Names |
RF-A, RP-A, RPA, Replication factor A protein 1, Replication protein A, Single-stranded DNA-binding protein |
Species |
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) |
KEGG Pathway |
mth:MTH_1385 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for O27438
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2K50 | NMR | - | A | 62-167 | PDB |
| AF-O27438-F1 | Predicted | AlphaFoldDB |
No variants for O27438
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O27438 | |||||
No associated diseases with O27438
4 regional properties for O27438
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type | 81 - 140 | IPR004365-1 |
| domain | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type | 192 - 273 | IPR004365-2 |
| domain | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type | 301 - 364 | IPR004365-3 |
| domain | Replication factor A, C-terminal | 678 - 781 | IPR013955 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKEELKREYE | RIKDRISPEE | FEELIEKKKE | ELGDIGFMDD | LTIASTVVDD | ILKEKNTMLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKPEHRMDTI | SKLEEGAETP | VTGRVMKISS | PRTFTTRKGR | EGKLANVIIA | DDTGELRAVF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WTENIKLLKK | FREGDVIRIK | DVNIRGGFGG | RKEAHLMPRS | TVEVLDPEDY | PEFPEYREEI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TPIGDLVEDD | EVNVIARITG | VSRVRTFERD | GREGRFISLD | IMDATGSTTY | TLWNNDVNLV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EELGLKEGDA | VKILWAQPRR | RDDKVTLTHT | SLTRVVPGEY | DVPEFREELV | KIGDLHEMRN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VTVMGLVTKV | NDPVEFERND | GTTGSVKSIE | IADDTGSARV | TLWDEDTRIK | INKGDIIRIS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GANVEFDDFN | QSYRINTNFN | TRITLNPESD | GALLKVLEEY | REQMRPMKIS | EILEMEDEGE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EVDVVGRIFS | LSDPREFERE | DGTGIVRSME | LADETGKIRI | SLWDEKAEKP | MNIGDAVRIE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NARIRLGLYS | VELSAGRTTR | IVNPLPEDME | DLPSFEELEE | MLYQTKKIAD | LEEDDRNIRI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IARVVDLFEP | REFQRGDGTP | GLVRTAEFAD | DTGSIRASLW | DDAAEKPLSI | GDPVKIENPR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VVFRDDMGGG | RLELSIGNSS | RIEPASERDL | EGLPSFDELQ | EMLYPHRDIA | DLDEDSRNVL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IEGELIEMSG | RRILSIKCPS | CNERLDLSDE | NICNFCGELV | DEPRYLLMIP | GRIMDDTGEV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MITFFGREAE | SILEMTTDEV | VNIINQSADE | SALEERVEDL | NGVTVRVIGN | ADMDVYSEEL |
| 790 | |||||
| RFIPRKVVKK | EL |