O27397

PR
Gene name
MTH_1342
Protein name
Probable N-glycosylase/DNA lyase
Names
Species
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
KEGG Pathway
mth:MTH_1342
EC number
4.2.99.18: Other carbon-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O27397

Entry ID Method Resolution Chain Position Source
AF-O27397-F1 Predicted AlphaFoldDB

No variants for O27397

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O27397

No associated diseases with O27397

3 regional properties for O27397

Type Name Position InterPro Accession
domain AAA+ ATPase domain 156 - 291 IPR003593
domain ATPase, AAA-type, core 160 - 288 IPR003959
conserved_site ATPase, AAA-type, conserved site 261 - 280 IPR003960

Functions

Description
EC Number 4.2.99.18 Other carbon-oxygen lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar.
class I DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.
damaged DNA binding Binding to damaged DNA.

2 GO annotations of biological process

Name Definition
base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRIPVGDFDL EMTQRSGQTS QPPWREVEGA FRELLIIEGV PCPVEVRNEA GVLRVRPYVD
70 80 90 100 110 120
VPQKTLREKI EYIFDLKFDI EDFYTFLEDK NLSYTLDSSR GLRLFLAKDP FECVISSIAS
130 140 150 160 170 180
ANCSVVRWTR SIEDIRRLWG QANTFNGETF HTFPSPHVLT GVAEGSLEDL QRAEDNLPSD
190 200 210 220 230 240
FSFNDLRSCG VGYRAPYIRE TSRILAEEMD IRRIDGMDYD DARELLLELS GVGPKVADCI
250 260 270 280 290 300
LLYGFRKTEA FPVDVWIRRI MNHIHPGRNF NDRSMVEFAR REYGEMADYV QLYLFNHARR
310
SGLLDRLRQG TG