O27376

PR
Gene name
srp54
Protein name
Signal recognition particle 54 kDa protein
Names
SRP54
Species
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
KEGG Pathway
mth:MTH_1321
EC number
3.6.5.4: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O27376

Entry ID Method Resolution Chain Position Source
AF-O27376-F1 Predicted AlphaFoldDB

No variants for O27376

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O27376

No associated diseases with O27376

1 regional properties for O27376

Type Name Position InterPro Accession
domain Replication protein A, C-terminal 197 - 254 IPR014892

Functions

Description
EC Number 3.6.5.4 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
  • The SRP-RNC complex is targeted to the cytoplasmic membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes.

3 GO annotations of molecular function

Name Definition
7S RNA binding Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP).
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

1 GO annotations of biological process

Name Definition
SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLGNLGRSLS KTMKKLAGMT IVDEEVVREV IKDIQRALIQ SDVNIKLVFN LSKSIEERAL
70 80 90 100 110 120
NEEPPKGITP KEHIISIVYD EMVKLLGEKS HELVIDDKPY RILFLGLQGS GKTTTIGKLA
130 140 150 160 170 180
RYLRKKGFTV GVVCTDTWRP AALEQLKQYT EGQDVSIYGD PQNRDALDLA EKGLARFQKK
190 200 210 220 230 240
DVIIFDTAGR HKEEKDLLRE MEELSAIVEP HEAILVIDGT IGQQAREQAL AFRKATDIGS
250 260 270 280 290 300
IIVTKLDGSA KGGGALSAVA EIGAPIKFIG TGERIDDLEV FDPERFISRL LGMGDLRSLL
310 320 330 340 350 360
EKVEEVSEEE IAEESLDAIL SGKFTLRDMR VQFEMMGKMG PLQQVMSMLP GAGKLPKDAS
370 380 390 400 410 420
RMTEETIRKY LIIMDSMTEE ELEKPDIIKH SRIRRIARGS GTRNEDVKEL LKYYRVTKKA
430 440
MKGLGRRKMG GPMGQLMRQF MR