O27211
Gene name |
hmd (mth, MTH_1142) |
Protein name |
5,10-methenyltetrahydromethanopterin hydrogenase |
Names |
H(2)-dependent methylene-H(4)MPT dehydrogenase, H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase, N(5),N(10)-methenyltetrahydromethanopterin hydrogenase |
Species |
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) |
KEGG Pathway |
mth:MTH_1142 |
EC number |
1.12.98.2: With other, known, acceptors |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O27211
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O27211-F1 | Predicted | AlphaFoldDB |
No variants for O27211
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O27211 | |||||
No associated diseases with O27211
5 regional properties for O27211
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | S-adenosylmethionine synthetase, N-terminal | 5 - 102 | IPR022628 |
| domain | S-adenosylmethionine synthetase, central domain | 126 - 252 | IPR022629 |
| domain | S-adenosylmethionine synthetase, C-terminal | 254 - 400 | IPR022630 |
| conserved_site | S-adenosylmethionine synthetase, conserved site | 127 - 137 | IPR022631-1 |
| conserved_site | S-adenosylmethionine synthetase, conserved site | 280 - 288 | IPR022631-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.12.98.2 | With other, known, acceptors |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| N5,N10-methenyltetrahydromethanopterin hydrogenase activity | Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H(+). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| methanogenesis, from carbon dioxide | The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2). |
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKLAILGAGC | YRTHAASGIT | NFSRACEVAE | MVGKPEIAMT | HSTITMGAEL | KELAGVDEVV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VADPVFDNQF | TVIDDFAYED | VIEAHKEDPE | KIMPQIREKV | NEVAKELPKP | PEGAIHFTHP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EDLGFEITTD | DREAVADADF | IMTWFPKGDM | QPGIIDKFID | DIKPGAIVTH | ACTIPTTKFY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KIFEEKHGDL | VTKPETLNVT | SYHPGAVPEM | KGQVYIAEGY | ASEEAINTLF | ELGQKARGNA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YRLPAELLGP | VCDMCSALTA | ITYAGILSYR | DSVTQVLGAP | AGFAQMMAKE | SLEQITALME |
| 310 | 320 | 330 | 340 | ||
| KVGIDKMEEH | LDPGALLGTA | DSMNFGASAD | ILPTVFEILE | KRKK |