O27194

PR
Gene name
serS (MTH_1122)
Protein name
Type-2 serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
KEGG Pathway
mth:MTH_1122
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O27194

Entry ID Method Resolution Chain Position Source
AF-O27194-F1 Predicted AlphaFoldDB

No variants for O27194

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O27194

No associated diseases with O27194

2 regional properties for O27194

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 306 - 478 IPR002314
domain Serine-tRNA ligase type 2, tRNA-binding domain 1 - 163 IPR041293

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKFKLKGIIK LSKEVPGIED DLEKFFTEAE SDILRRGVPE GQEHEAAHIK SWRLEGDTLH
70 80 90 100 110 120
IEMESGRRVR AHDGLLRLKK PLGQLLGPKY RVGVRGISVT DYTMEMKAPG VSGIPSLAEL
130 140 150 160 170 180
PFVEDAAITD GTIMVRFQPL EESDLRKHVF DRVVKHARTL VESSDDLTVQ VTRATPGEII
190 200 210 220 230 240
ARSRSRDFFF EGDPTEEAMR LGWVKKFPGR GQWFYGPKIT ALHRALEEFF IERIVKPLGF
250 260 270 280 290 300
VECLFPKLIP LDIMNKMRYL EGLPEGMYYC SAPSRDPETF EEFKNELIIN REVPMDLLKR
310 320 330 340 350 360
GIKDPGYVIA PAQCEPFYQF LSHEVVSAED LPVKFFDRSG WTYRWEAGGS KGLDRVHEFQ
370 380 390 400 410 420
RVELVWLAEP GETEEIRDRT VELSHDAADE LELEWYTEVG DDPFYLEGRK VEERGIEFPD
430 440 450 460 470 480
VPKYEMRLSL PGREKGVAVV SANVHGTHFI EGFSIREARN LNIWTGCTGI GLSRWIYGFL
490 500 510
AQKGFETGNW PDFIGERVEG VENPRIITWP RQD