O27051

PR
Gene name
serA (MTH_970)
Protein name
D-3-phosphoglycerate dehydrogenase
Names
PGDH
Species
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
KEGG Pathway
mth:MTH_970
EC number
1.1.1.95: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

230-308 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O27051

Entry ID Method Resolution Chain Position Source
AF-O27051-F1 Predicted AlphaFoldDB

No variants for O27051

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O27051

No associated diseases with O27051

2 regional properties for O27051

Type Name Position InterPro Accession
domain Replication modulator SeqA, C-terminal DNA-binding domain 70 - 178 IPR026577
domain Negative modulator of initiation of replication SeqA, N-terminal 1 - 36 IPR033761

Functions

Description
EC Number 1.1.1.95 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
phosphoglycerate dehydrogenase activity Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.

1 GO annotations of biological process

Name Definition
L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSRMKVLIAD SINEKGISEL EEVAEVVVNT TITPEELLDA IKDFDAIVVR SRTKVTREVI
70 80 90 100 110 120
EAAPRLKIIA RAGVGVDNVD VKAATDRGIM VINAPESTSI TVAEHSIGLM LALARKIAIA
130 140 150 160 170 180
DRSVKEGKWE KNRFMGIELN GKTLGIIGMG RIGSQVVVRT KAFGMDIMVY DPYISKEAAE
190 200 210 220 230 240
EMGVTVTDLE TLLRESDIVT IHVPLTPETR HLISEDEFKL MKDTAFIVNC ARGGIIDEDA
250 260 270 280 290 300
LYRALKDGEI AGAALDVFEE EPPEGSPLLE LENVVLTPHI GASTSEAQRD AAIIVANEIK
310 320 330 340 350 360
TVFQGGAPRN VLNMPVMDSE TYKSLKPYIE LAEKMGAIIA QALPGNIEKL DVTYCGELAE
370 380 390 400 410 420
MQFDILTRTM LQAILNPILT EPVNLINAPS IAKKRGIMVT EARRSESDGY RSIIIATAES
430 440 450 460 470 480
DRGGFSVEAT HIKEPTIIGI NGYRVDVKPE GTMIIARYRD LPGTIGAIGT KLGQHGINIA
490 500 510 520
TMQVGRKEIG GEAVMVLKVD QSVPAEVIEE VKKLDNVDDA VAIEI