O26949

PR
Gene name
thiN (MTH_861)
Protein name
Thiamine-phosphate synthase ThiN
Names
TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase
Species
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
KEGG Pathway
mth:MTH_861
EC number
2.5.1.3: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

86-163 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O26949

Entry ID Method Resolution Chain Position Source
AF-O26949-F1 Predicted AlphaFoldDB

No variants for O26949

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O26949

No associated diseases with O26949

No regional properties for O26949

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O26949

Functions

Description
EC Number 2.5.1.3 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
thiamine-phosphate diphosphorylase activity Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate.

2 GO annotations of biological process

Name Definition
thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
thiamine diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMIMEIENVR RALEMISSAE DFGILIPEVR SNIVMARSNP CGPEDVVAVP GRITEFQGRA
70 80 90 100 110 120
FACRDPEYGA SSHMARFIIA LNEHLPGRRS ALNIKFDESI ISICEDMGLV VSSYDRSREP
130 140 150 160 170 180
DSVRDTEGGS IPWGVEEALR NSESPPDVIY HRGAWGKEPM IVLTGRDAVE VAELAIKILR
KYKSLKGDTR