O26780

PR
Gene name
rrp4
Protein name
Exosome complex component Rrp4
Names
Species
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
KEGG Pathway
mth:MTH_684
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

195-311 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O26780

Entry ID Method Resolution Chain Position Source
AF-O26780-F1 Predicted AlphaFoldDB

No variants for O26780

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O26780

No associated diseases with O26780

2 regional properties for O26780

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 31 - 166 IPR001247
domain Exoribonuclease, phosphorolytic domain 2 182 - 246 IPR015847

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.

1 GO annotations of molecular function

Name Definition
poly(A) binding Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.

1 GO annotations of biological process

Name Definition
RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLLVNEKDLV VPGQVLAENE YFPGRGTFKE DNRICSSFVG LVSVRNKKIN VIPLQSKYIP
70 80 90 100 110 120
KRGDVVIGEI TDIRFSMWGL DINSPYTGLL PASEVFGKDK RELESVFDIV DVLLLRVVDV
130 140 150 160 170 180
DEVKKVKLGL KGRGLGKFRD GILVYITPTK VPRLIGKRGS MINMVKEKTH CDIVVGQNGV
190 200 210 220 230 240
VWIKGEPDME RIAEKVVLMI DREAHTSGLT DRVRELLDRL TGVEPEIQVE ESEGTEKPET
250 260 270 280 290 300
PESEDFEEAS DYSEDVEVSP ESEDIEEVSD ESEDLEVESE DVEEGTDTPA AEEDDGEAGD
310
AEVKDENNSE R