O26377

PR
Gene name
MTH_277
Protein name
Digeranylgeranylglycerophospholipid reductase 1
Names
DGGGPL reductase 1, 2,3-bis-O-geranylgeranylglyceryl phosphate reductase 1, Geranylgeranyl reductase 1, GGR 1
Species
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
KEGG Pathway
mth:MTH_277
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O26377

Entry ID Method Resolution Chain Position Source
AF-O26377-F1 Predicted AlphaFoldDB

No variants for O26377

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O26377

No associated diseases with O26377

3 regional properties for O26377

Type Name Position InterPro Accession
domain Helicase, C-terminal 386 - 542 IPR001650
domain DEAD/DEAH box helicase domain 162 - 346 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 157 - 376 IPR014001

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
geranylgeranyl reductase activity Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group.
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.

3 GO annotations of biological process

Name Definition
glycerophospholipid metabolic process The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
membrane lipid biosynthetic process The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane.
phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIIMVTEVDV LVIGAGPAGS TAAKHAALGG ADVLLIDKKS EIGAPKRCAE GVSIGGLESL
70 80 90 100 110 120
GIEPNPRWIT KKLDGVRMVS PNGTDVWLTS DKVELPEAGY ILERKVFDKF MAMDAARAGS
130 140 150 160 170 180
RIMVKTIATG MERTDDGYLV SAECMGEKFE IKARIVIAAD GPESRVARWA GLNTATRPKD
190 200 210 220 230 240
MESAAQFEMV GVEMEDNNCI EFYFGSVAPG GYALDIPEGD DIANVGLGVL STETDKSAYE
250 260 270 280 290 300
HLLEFVESCP ATRNAQPVEL NIGGDPVGGM PKKLVADSLM VVGDAAGQVN PLTGGGIISG
310 320 330 340 350 360
MKGGMLAGQV AAAAVSEGDV TARRLGEYER LCREEIGDEI SKYLKVKEYL LTLSDSELDS
370 380 390
IAEAFQDVEF EKVSTTELVK KLIKVSPKAL LKLGKLF