O26369

PR
Gene name
argH
Protein name
Argininosuccinate lyase
Names
ASAL, Arginosuccinase
Species
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
KEGG Pathway
mth:MTH_269
EC number
4.3.2.1: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

242-313 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O26369

Entry ID Method Resolution Chain Position Source
AF-O26369-F1 Predicted AlphaFoldDB

No variants for O26369

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O26369

No associated diseases with O26369

2 regional properties for O26369

Type Name Position InterPro Accession
domain Fumarate lyase, N-terminal 17 - 299 IPR022761
domain Argininosuccinate lyase, C-terminal 362 - 438 IPR029419

Functions

Description
EC Number 4.3.2.1 Lyases acting on amides, amidines, etc
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.

1 GO annotations of biological process

Name Definition
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNLRAGRLNS GMEDEAAEFT SSLTFDHHIF EADIECNMAH TRMLAHEGII PEEVAAKIID
70 80 90 100 110 120
ALESLREEGI EALDMDPSVE DIHMAVENYV TARIGEEAGF MHTGKSRNDQ VATDLRLALR
130 140 150 160 170 180
ERIRTISREL LDFIDSISDL ALDHTETVMV GYTHLQHAQP TTLGHHLMAY ASSLRRDYER
190 200 210 220 230 240
LQDTLKRVDQ NPLGSAAMTT TSFPINRELT TRLLGFSDYM KNSMDAVSAR DFIAETVFDL
250 260 270 280 290 300
SMLAVNLSRI SEEMILWSTH EFGIVEIPDE FSSTSSIMPQ KKNPDVAEIA RAKTSTVQGE
310 320 330 340 350 360
LVTILGIMKA LPYTYNRDLQ EVTPHLWRAV DTVLSMIRVV RGMLLGIRVN RNRALELAGA
370 380 390 400 410 420
NFATATDLAD IIVRERGIPF RVAHRIVGRL VTRAIEDGLA PGDVDSVYLD EVSLEVTGRK
430 440 450 460
LELDPELVEK ALDPLENVRM RRIPGGPAPE MVRVAVEEMK SFIESERK