O26350
Gene name |
fno (MTH_248) |
Protein name |
F420-dependent NADP reductase |
Names |
F420H2:NADP oxidoreductase |
Species |
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) |
KEGG Pathway |
mth:MTH_248 |
EC number |
1.5.1.40: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O26350
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O26350-F1 | Predicted | AlphaFoldDB |
No variants for O26350
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O26350 | |||||
No associated diseases with O26350
No regional properties for O26350
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O26350 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.5.1.40 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity | Catalysis of the reaction: NADP + a reduced coenzyme F420 <=> NADPH + H+ + an oxidized coenzyme F420. |
| coenzyme F420 binding | Binding to F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
| NADP binding | Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. |
| reduced coenzyme F420:NADP+ oxidoreductase activity | Catalysis of the reaction: NADP+ + 1,5-dihydrocoenzyme F420 = NADPH + H+ + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| NADPH regeneration | A metabolic process that generates a pool of NADPH by the reduction of NADP+. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIKVMVMKIA | VIGGTGDQGL | GLALRFAVAG | EEVIIGSRDA | EKASKAASKV | LEIAGRDDIS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VEGATNPDAA | ASADVVVLTV | PLQAQMVTLA | SIRDQVRDKV | LIDATVPIDS | CIGGSAVRYI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DLWEGSAAER | AARFLREQGT | RVAAAFNNIS | ASALLEVSEP | VDCDCLVASD | HRDALEVAAE |
| 190 | 200 | 210 | 220 | 230 | |
| LAEKIDGVRA | IECGGLENAR | IIEKITPLLI | NLNIRNRVRN | AGIRITNLPE | QE |