O26310

PR
Gene name
polB2 (MTH_208)
Protein name
DNA polymerase PolB subunit 2
Names
Species
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
KEGG Pathway
mth:MTH_208
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

173-223 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O26310

Entry ID Method Resolution Chain Position Source
AF-O26310-F1 Predicted AlphaFoldDB

No variants for O26310

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O26310

No associated diseases with O26310

1 regional properties for O26310

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family B, multifunctional domain 12 - 198 IPR006134

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSQLSKVEDE ILSQVKRFLK HINSNLPEGM ELEFEGFYRR GFFVTKKRYA LIEDDTIVAK
70 80 90 100 110 120
GLELVRRDWA PIAKKTQRKV LMAILRDGSP EKAREIIREV VGRIRRGDVE LDDLVIHTQI
130 140 150 160 170 180
TRDLSEYKQI GPHVIAAKRS LEKGRRVERG SIVRYIIVKG RGPISQRAFP VEDAEGMGYD
190 200 210 220
PDYYIENQVM AAVSRIMSSL GYSTEDMNSL SSGERQSSLD AFF