Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for O25458

Entry ID Method Resolution Chain Position Source
AF-O25458-F1 Predicted AlphaFoldDB

No variants for O25458

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O25458

No associated diseases with O25458

4 regional properties for O25458

Type Name Position InterPro Accession
domain FtsK domain 600 - 839 IPR002543
domain FtsK gamma domain 917 - 982 IPR018541
domain DNA translocase FtsK, 4TM region 29 - 199 IPR025199
domain FtsK alpha domain 492 - 592 IPR041027

Functions

Description
EC Number 3.6.5.4 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Cell inner membrane; Peripheral membrane protein; Cytoplasmic side
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intrinsic component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

1 GO annotations of biological process

Name Definition
SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFNFFKKIVN KIKGEEAKEK KRQSVPKEEL EEILIGFDIQ YDLIESLLKH LGDLITPKQL
70 80 90 100 110 120
EVALLRFVRG DSYYDKTRLK TITTKPLVHL IVGVNGAGKT TTIAKLAKLS LKQHKKALLG
130 140 150 160 170 180
AGDTFRAAAV KQLQLWGEKL NIQVISAKEG SDPSSLAYNT IESAIAKNID EVFIDTAGRL
190 200 210 220 230 240
HNQTNLKNEL SKIARTCSKV LKDAPFYKFL ILDGTQGSSG LTQAKIFHET LALDGVIMTK
250 260 270 280 290
LDGTSKGGAI LSVLYELKLP ILYLGMGEKE DDLIAFDEER FIEDLVDAVF VGQ