O25029

PR
Gene name
rhpA (HP_0247, C694_01250)
Protein name
DEAD-box ATP-dependent RNA helicase RhpA
Names
Species
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
KEGG Pathway
hpy:HP_0247
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O25029

Entry ID Method Resolution Chain Position Source
AF-O25029-F1 Predicted AlphaFoldDB

No variants for O25029

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O25029

No associated diseases with O25029

4 regional properties for O25029

Type Name Position InterPro Accession
domain Helicase, C-terminal 231 - 393 IPR001650
domain DEAD/DEAH box helicase domain 45 - 209 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 39 - 235 IPR014001
domain RNA helicase, DEAD-box type, Q motif 20 - 48 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
  • The RNaseJ-RhpA complex co-localizes with 70S ribosomes and polysomes; remains associated with ribosomes in the absence of RNase J
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.
RNA strand annealing activity An activity that facilitates the formation of a complementary double-stranded RNA molecule.

1 GO annotations of biological process

Name Definition
ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELNQPPLPT EIDGDAYHKP SFNDLGLKES VLKSVYEAGF TSPSPIQEKA IPAVLQGRDV
70 80 90 100 110 120
IAQAQTGTGK TAAFALPIIN NLKNNHTIEA LVITPTRELA MQISDEIFKL GKHTRTKTVC
130 140 150 160 170 180
VYGGQSVKKQ CEFIKKNPQV MIATPGRLLD HLKNERIHKF VPKVVVLDES DEMLDMGFLD
190 200 210 220 230 240
DIEEIFDYLP SEAQILLFSA TMPEPIKRLA DKILENPIKI HIAPSNITNT DITQRFYVIN
250 260 270 280 290 300
EHERAEAIMR LLDTQAPKKS IVFTRTKKEA DELHQFLASK NYKSTALHGD MDQRDRRSSI
310 320 330 340 350 360
MAFKKNDADV LVATDVASRG LDISGVSHVF NYHLPLNTES YIHRIGRTGR AGKKGMAITL
370 380 390 400 410 420
VTPLEYKELL RMQKEIDSEI ELFEIPTINE NQIIKTLHDA KVSEGIISLY EQLTEIFEPS
430 440 450 460 470 480
QLVLKLLSLQ FETSKIGLNQ QEIDAIQNPK EKTPKPSNKK TPQHERARSF KKGQHRDRHP
490
KTNHYSKKPK RR