O23255
Gene name |
SAHH1 |
Protein name |
Adenosylhomocysteinase 1 |
Names |
AdoHcyase 1, Protein EMBRYO DEFECTIVE 1395, Protein HOMOLOGY-DEPENDENT GENE SILENCING 1, S-adenosyl-L-homocysteine hydrolase 1, SAH hydrolase 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G13940 |
EC number |
3.13.2.1: Thioether and trialkylsulfonium hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O23255
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O23255-F1 | Predicted | AlphaFoldDB |
8 variants for O23255
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14180597 | 20 | S>A | No | 1000Genomes | |
| tmp_4_8055222_G_A | 98 | A>T | No | 1000Genomes | |
| ENSVATH00501347 | 158 | E>G | No | 1000Genomes | |
| tmp_4_8055417_G_A | 163 | V>I | No | 1000Genomes | |
| tmp_4_8055486_C_A | 186 | Q>K | No | 1000Genomes | |
| ENSVATH11684752 | 187 | V>I | No | 1000Genomes | |
| tmp_4_8055495_C_G | 189 | P>A | No | 1000Genomes | |
| ENSVATH14180604 | 438 | V>I | No | 1000Genomes |
No associated diseases with O23255
3 regional properties for O23255
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | S-adenosyl-L-homocysteine hydrolase, NAD binding domain | 240 - 403 | IPR015878 |
| conserved_site | S-adenosyl-L-homocysteine hydrolase, conserved site | 85 - 99 | IPR020082-1 |
| conserved_site | S-adenosyl-L-homocysteine hydrolase, conserved site | 262 - 279 | IPR020082-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.13.2.1 | Thioether and trialkylsulfonium hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
| vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| adenosylhomocysteinase activity | Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. |
| copper ion binding | Binding to a copper (Cu) ion. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA methylation-dependent heterochromatin assembly | Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. |
| embryo development ending in seed dormancy | The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana. |
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
| post-transcriptional gene silencing | The inactivation of gene expression that occurs after thanscription. |
| S-adenosylmethionine cycle | A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALLVEKTSS | GREYKVKDMS | QADFGRLELE | LAEVEMPGLM | ACRTEFGPSQ | PFKGARITGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LHMTIQTAVL | IETLTALGAE | VRWCSCNIFS | TQDHAAAAIA | RDSAAVFAWK | GETLQEYWWC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TERALDWGPG | GGPDLIVDDG | GDATLLIHEG | VKAEEIFEKT | GQVPDPTSTD | NPEFQIVLSI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IKEGLQVDPK | KYHKMKERLV | GVSEETTTGV | KRLYQMQQNG | TLLFPAINVN | DSVTKSKFDN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LYGCRHSLPD | GLMRATDVMI | AGKVAVICGY | GDVGKGCAAA | MKTAGARVIV | TEIDPICALQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ALMEGLQVLT | LEDVVSEADI | FVTTTGNKDI | IMVDHMRKMK | NNAIVCNIGH | FDNEIDMLGL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ETYPGVKRIT | IKPQTDRWVF | PETKAGIIVL | AEGRLMNLGC | ATGHPSFVMS | CSFTNQVIAQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LELWNEKASG | KYEKKVYVLP | KHLDEKVALL | HLGKLGARLT | KLSKDQSDYV | SIPIEGPYKP |
| PHYRY |