O22928
Gene name |
At2g30320 (T09D09.13) |
Protein name |
Putative tRNA pseudouridine synthase |
Names |
tRNA pseudouridylate synthase, tRNA-uridine isomerase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G30320 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O22928
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O22928-F1 | Predicted | AlphaFoldDB |
49 variants for O22928
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH13479764 | 9 | P>R | No | 1000Genomes | |
| ENSVATH00254742 | 16 | W>L | No | 1000Genomes | |
| ENSVATH00254741 | 19 | T>S | No | 1000Genomes | |
| ENSVATH13479763 | 20 | R>Q | No | 1000Genomes | |
| ENSVATH01928716 | 31 | F>S | No | 1000Genomes | |
| tmp_2_12927698_T_G | 67 | I>L | No | 1000Genomes | |
| tmp_2_12927553_G_T | 86 | P>H | No | 1000Genomes | |
| ENSVATH01928714 | 87 | S>F | No | 1000Genomes | |
| tmp_2_12927367_C_A | 97 | V>F | No | 1000Genomes | |
| ENSVATH01928709 | 134 | S>T | No | 1000Genomes | |
| ENSVATH05630494 | 167 | I>V | No | 1000Genomes | |
| tmp_2_12926816_T_C | 210 | I>V | No | 1000Genomes | |
| ENSVATH13479756 | 214 | I>F | No | 1000Genomes | |
| tmp_2_12926669_G_C | 229 | P>A | No | 1000Genomes | |
| tmp_2_12926600_C_T | 252 | G>R | No | 1000Genomes | |
| ENSVATH05630491 | 253 | R>H | No | 1000Genomes | |
| ENSVATH05630490 | 259 | K>N | No | 1000Genomes | |
| tmp_2_12926548_C_T | 269 | R>K | No | 1000Genomes | |
| ENSVATH13479755 | 272 | N>S | No | 1000Genomes | |
| tmp_2_12926533_A_G | 274 | I>T | No | 1000Genomes | |
| tmp_2_12926500_ACTTCTTTTT_CCTTCTTTTT,A | 285 | V>G | No | 1000Genomes | |
| ENSVATH13479742 | 297 | D>G | No | 1000Genomes | |
| tmp_2_12926449_T_G | 302 | Q>P | No | 1000Genomes | |
| ENSVATH00254739 | 304 | Y>H | No | 1000Genomes | |
| tmp_2_12926420_C_T | 312 | E>K | No | 1000Genomes | |
| ENSVATH13479740 | 339 | L>H | No | 1000Genomes | |
| ENSVATH05630489 | 348 | I>M | No | 1000Genomes | |
| tmp_2_12926177_T_C | 362 | I>V | No | 1000Genomes | |
| ENSVATH05630487 | 371 | E>D | No | 1000Genomes | |
| tmp_2_12926131_A_G | 377 | I>T | No | 1000Genomes | |
| ENSVATH14572529 | 413 | R>K | No | 1000Genomes | |
| ENSVATH05630484 | 415 | G>V | No | 1000Genomes | |
| ENSVATH01928705 | 418 | A>E | No | 1000Genomes | |
| ENSVATH14572528 | 431 | E>D | No | 1000Genomes | |
| ENSVATH05630483 | 438 | V>L | No | 1000Genomes | |
| ENSVATH05630482 | 446 | D>N | No | 1000Genomes | |
| ENSVATH01928703 | 450 | S>C | No | 1000Genomes | |
| ENSVATH01928700 | 468 | E>D | No | 1000Genomes | |
| ENSVATH00254736 | 471 | E>K | No | 1000Genomes | |
| tmp_2_12925847_C_T | 472 | D>N | No | 1000Genomes | |
| ENSVATH01928699 | 475 | K>R | No | 1000Genomes | |
| tmp_2_12925829_C_T | 478 | E>K | No | 1000Genomes | |
| ENSVATH05630481 | 480 | W>R | No | 1000Genomes | |
| ENSVATH05630480 | 482 | A>D | No | 1000Genomes | |
| tmp_2_12925807_G_C | 485 | P>R | No | 1000Genomes | |
| tmp_2_12925794_C_A | 489 | L>F | No | 1000Genomes | |
| tmp_2_12925793_T_A | 490 | K>* | No | 1000Genomes | |
| ENSVATH05630477 | 498 | A>T | No | 1000Genomes | |
| ENSVATH05630475 | 510 | L>V | No | 1000Genomes |
No associated diseases with O22928
1 regional properties for O22928
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pseudouridine synthase I, TruA, alpha/beta domain | 221 - 398 | IPR020097 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| pseudouridine synthase activity | Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in an mRNA molecule. |
| tRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVSFLRIPI | PSRVFWYPTR | LIRVTPALLR | FSSSAAFQPS | STSLSPPSSD | NFLADKWESY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RKKKVVIRIG | YVGTDYRGLQ | IQRDDPSIKT | IEGELEVAIY | KAGGIRDSNY | GDLHKIGWAR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSRTDKGVHS | LATSISLKME | IPETAWKDDP | QGTVLAKCIS | KHLPENIRVF | SVLPSNRRFD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PRRECTLRKY | SYLLPVDVLG | IKNSFTSDEI | DYHITDFNEI | LKEFEGEYPF | HNYTQRSRYR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RKSEQKIKQR | NGRPPREPKS | IKASESEFRE | ENHIEIGEEE | EEKEVDGESD | EHVVTPDSDN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SQVYSRAKWL | YEPDETDKIS | GAHFRKVFRC | RSGKLENSLG | FGFVEISIWG | ESFMLHQIRK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MIGTAVAVKR | ELLPRDIIRL | SLNKFTRIVL | PLAPSEVLIL | RGNSFEVRRL | PERPGMEATG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ESEEVEKEIE | EFYRAVMVPQ | VSIFLDSEKS | PWKEWVDHLD | RNDGLIDEEL | EDVRKGWEEW |
| 490 | 500 | ||||
| KAAKPWMNLK | KTEDDEEALS | SVSVPIHQAL |