O19177

PR
Gene name
UNC119 (RG4)
Protein name
Protein unc-119 homolog A
Names
CRG4, Retinal protein 4
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-88 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O19177

Entry ID Method Resolution Chain Position Source
AF-O19177-F1 Predicted AlphaFoldDB

No variants for O19177

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O19177

No associated diseases with O19177

1 regional properties for O19177

Type Name Position InterPro Accession
domain GMP phosphodiesterase, delta subunit 80 - 236 IPR008015

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cytoplasm, cytoskeleton, spindle
  • Cytoplasm, cytoskeleton, spindle pole
  • ocalizes to the centrosome in interphase cells and begins to translocate from the spindle pole to the spindle midzone after the onset of mitosis; it then localizes to the intercellular bridge in telophase cells and to the midbody in cytokinetic cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intercellular bridge A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
spindle midzone The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

1 GO annotations of molecular function

Name Definition
lipid binding Binding to a lipid.

9 GO annotations of biological process

Name Definition
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
lipoprotein transport The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
mitotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
negative regulation of caveolin-mediated endocytosis Any process that stops, prevents or reduces the frequency, rate or extent of caveolin-mediated endocytosis.
negative regulation of clathrin-dependent endocytosis Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-mediated endocytosis.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
positive regulation of protein tyrosine kinase activity Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SYR2 UNC119 Protein unc-119 homolog A Bos taurus (Bovine) PR
Q13432 UNC119 Protein unc-119 homolog A Homo sapiens (Human) PR
Q9Z2R6 Unc119 Protein unc-119 homolog A Mus musculus (Mouse) PR
Q62885 Unc119 Protein unc-119 homolog A Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MKVKKGGGGA GTGAEPASGA PGPSVEPKPE PQAESESGSE SEPEAGPGPR PGPLQRKQRI
70 80 90 100 110 120
GPEDVLGLQR ITGDYLCSPE ENIYKIDFIR FKIRDMDSGT VLFEIKKPPA SERLPINRRD
130 140 150 160 170 180
LDPNAGRFVR YQFTPAFLRL RQVGATVEFT VGDKPVNNFR MIERHYFRNQ LLKSFDFHFG
190 200 210 220 230
FCIPSSKNTC EHIYDFPPLS EELINEMIRH PYETQSDSFY FVDDRLVMHN KADYSYSGTP