O19104

PR
Gene name
FANCC (FACC)
Protein name
Fanconi anemia group C protein homolog
Names
Protein FACC
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281762
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

69-209 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O19104

Entry ID Method Resolution Chain Position Source
AF-O19104-F1 Predicted AlphaFoldDB

No variants for O19104

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O19104

No associated diseases with O19104

No regional properties for O19104

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O19104

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • The major form is nuclear
  • The minor form is cytoplasmic
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Fanconi anaemia nuclear complex A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
interstrand cross-link repair Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.
nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAEDSAGLPS NYQFWMQKLS VWTQASTLET QRDICLHLPQ FQEFLRRMYE TLKEMDSNAI
70 80 90 100 110 120
IERFPTICQL LAKSCWSPFI LAYDESPKIL IWCLCCLIKK DPQNSRESKL NSWTRRLLSH
130 140 150 160 170 180
IVSTSRFDIK EVGLFNQVLG YAPTDYYPGL LKNMVLSLVS ELRENHLNGF SSQRRCPERV
190 200 210 220 230 240
RSLSRDRVPL LTLPDFEPLV EALLTYHGHE PQEVLCPEFF DAVNEASLLK KISLPTSAIL
250 260 270 280 290 300
CLWLRHLPSL ENTMLHLLEK LISSERNSLR RIKCFMKDSL RPEAAACHPA IFRVVDEIFR
310 320 330 340 350 360
SALLETDGAP EVLAGLQVFT RCFVEALEKE NKQLKFALKT YFPYASPALV MVLLQHPKDI
370 380 390 400 410 420
PQGLWHQSLK HISEMLKEIV EDHGSYGGPF ESWFLFVHFG GWADITAEQL LMSEAEAEPP
430 440 450 460 470 480
EALLWLLAFS CSPGAGHQQR ARTMVEVKTV LGCLTKLFRS PALSARDLQA AAGENLGGDP
490 500 510 520 530 540
RPPACQQLVR RLLLHFLLWA PGGHTIAREV ITLMAQTDAI MNEIIGFLDY TLYRWDHLCV
550 560
EAHRSRKLAR ELLTELREQA LPGQVNQ