O18750

PR
Gene name
HSP90B1 (GRP94)
Protein name
Endoplasmin
Names
94 kDa glucose-regulated protein, GRP-94, Heat shock protein 90 kDa beta member 1
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

653-716 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O18750

Entry ID Method Resolution Chain Position Source
AF-O18750-F1 Predicted AlphaFoldDB

No variants for O18750

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O18750

No associated diseases with O18750

3 regional properties for O18750

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 17 - 176 IPR003594
conserved_site Heat shock protein Hsp90, conserved site 15 - 24 IPR019805
domain Heat shock protein Hsp90, N-terminal 4 - 200 IPR020575

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum lumen
  • Sarcoplasmic reticulum lumen
  • Melanosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
sarcoplasmic reticulum lumen The volume enclosed by the membranes of the sarcoplasmic reticulum.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
unfolded protein binding Binding to an unfolded protein.

1 GO annotations of biological process

Name Definition
ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
AEVNRMMKLI INSLYKNKEI FLRELISNAS DALDKIRLIS LTDEQALSGN EELTVKIKCD
70 80 90 100 110 120
KEKNLLHVTD TGVGMTREEL VKNLGTIAKS GTSEFLNKMT EAQEDGQSTS ELIGQFGVGF
130 140 150 160 170 180
YSAFLVADKV IVTSKHNNDT QHIWESDSNE FSVIADPRGN TLGRGTTITL VLKEEASDYL
190 200 210 220 230 240
ELDTIKNLVK KYSQFINFPI YVWSSKTETV EEPAGEEEAA KEEKEEAVDE AAVEEEEEEK
250 260 270 280 290 300
KPKTKKVEKQ VWDWELMNDI KPIWQRPSKE VEEDEYKAFY KSFSKESDDP MAYIHFTAEE
310 320 330 340 350 360
STFKSILFVP TSAPRGLFDE YGSKKSDYIK LYVRRVFITD DFHDMMPKYL NFVKGVVDSD
370 380 390 400 410 420
DLPLNVSRET LQQHKLLKVI RKKLVRKTLD MIKKIADEKY NDDTFWKGTN IKLGVIEDHS
430 440 450 460 470 480
NRTRLAKLLR FQSSHHPTDI TSLDQYVERM KEKQDKIYFM AGASRKEAES SPFVERLLKK
490 500 510 520 530 540
GYEVIYLTEP VDEYCIQALP EFDGKRFQNV AKEGVKFDES EKTKESREAT EKEFEPLLNW
550 560 570 580 590 600
MKDKALKDKI EKAVVSQRLT ESPCALVASQ YGWSANMERI MKAQAYQTGK DSTKYYASQK
610 620 630 640 650 660
TFEINPRHPL IRDMLRIKED DKTVMDLAVV LFETAILRSG YLLPDTKAYG DRIERIVRLS
670 680 690 700 710
LNIDPDAKVE EEPEEEPEDT TEDTEQDEEE EMDAGTDEQE QEQEPEKKST AEKDEL