O16810

SS
Gene name
Orc1 (CG10667)
Protein name
Origin recognition complex subunit 1
Names
DmORC1
Species
Gallus gallus (Chicken)
KEGG Pathway
dme:Dmel_CG10667
EC number
Protein Class

Descriptions

HSPA8 (or hsc70) is a heat shock cognate protein involved in many cellular processes. During recovery from stress, HSPA8, initially accumulating in the nucleoplasm for folding/refolding of proteins, transiently concentrates in nucleoli for nucleolar morphology and function restoration. The inhibitory region is positioned at one of the three domains of HSPA8 protein, which is the N-terminal ATPase domain, specifically in residues 263-287 of domain IIB. Under normal growth conditions, the constitutive nucleolar targeting function that is provided by residues 225-262 is diminished by the autoinhibitory element located in residues 263-287. When cells recover from stress, the autoinhibitory element is inactivated, and the constitutive nucleolar targeting function restores.

Autoinhibitory domains (AIDs)

590-741 (ATPase domain) EV

Target domain

456-187 (BAH domain)

Relief mechanism

PTM

Assay

Structural analysis

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for O16810

Entry ID Method Resolution Chain Position Source
4XGC X-ray 350 A A 533-924 PDB
7JGR EM 390 A A 440-924 PDB
7JGS EM 320 A A 440-924 PDB
7JK2 EM 320 A A 440-924 PDB
7JK3 EM 340 A A 440-924 PDB
7JK4 EM 340 A A 440-924 PDB
7JK5 EM 390 A A 440-924 PDB
7JK6 EM 400 A A 440-924 PDB
AF-O16810-F1 Predicted AlphaFoldDB

No variants for O16810

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O16810

No associated diseases with O16810

2 regional properties for O16810

Type Name Position InterPro Accession
domain Gasdermin, pore forming domain 5 - 233 IPR040460
domain Gasdermin, PUB domain 274 - 440 IPR041263

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nuclear origin of replication recognition complex A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
metal ion binding Binding to a metal ion.

3 GO annotations of biological process

Name Definition
DNA amplification The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment.
DNA replication initiation The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
mitotic DNA replication checkpoint signaling A signal transduction process that contributes to a mitotic DNA replication checkpoint.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P54784 ORC1 Origin recognition complex subunit 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q58DC8 ORC1 Origin recognition complex subunit 1 Bos taurus (Bovine) PR
Q13415 ORC1 Origin recognition complex subunit 1 Homo sapiens (Human) PR
Q9Z1N2 Orc1 Origin recognition complex subunit 1 Mus musculus (Mouse) PR
Q80Z32 Orc1 Origin recognition complex subunit 1 Rattus norvegicus (Rat) PR
Q710E8 ORC1A Origin of replication complex subunit 1A Arabidopsis thaliana (Mouse-ear cress) PR
Q9SU24 ORC1B Origin of replication complex subunit 1B Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSGKGPAIGI DLGTTYSCVG VFQHGKVEII ANDQGNRTTP SYVAFTDTER LIGDAAKNQV
70 80 90 100 110 120
AMNPTNTIFD AKRLIGRKYD DPTVQSDMKH WPFRVVNEGG KPKVQVEYKG EMKTFFPEEI
130 140 150 160 170 180
SSMVLTKMKE IAEAYLGKKV ETAVITVPAY FNDSQRQATK DAGTITGLNV MRIINEPTAA
190 200 210 220 230 240
AIAYGLDKKG TRAGEKNVLI FDLGGGTFDV SILTIEDGIF EVKSTAGDTH LGGEDFDNRM
250 260 270 280 290 300
VNRFVEEFKG KHKRDNAGNK RAVRRLRTAC ERARRTLSSS TQASIEIDSL FEGIDFYTSI
310 320 330 340 350 360
TRARFEELNA DLFRGTLEPV EKALRDAKLD KGQIQEIVLV GGSTRIPKIQ KLLQDFFNGK
370 380 390 400 410 420
ELNKSINPDE AVAYGAAVQA AILMGDKSEN VQDLLLLDVT PLSLGIETAG GVMTALIKRN
430 440 450 460 470 480
TTIPTKQTQT FTTYSDNQSS VLVQVYEGER AMTKDNNLLG KFDLTGIPPA PRGVPQIEVT
490 500 510 520 530 540
FDIDANGILN VSAVDKSTGK ENKITITNDK GRLSKDDIDR MVQEAEKYKA EDEANRDRVG
550 560 570 580 590 600
AKNSLESYTY NMKQTVEDEK LKGKISDQDK QKVLDKCQEV ISSLDRNQMA EKEEYEHKQK
610 620 630
ELEKLCNPIV TKLYQGAGGA GAGGSGGPTI EEVD