AiPD: Autoinhibited Protein Database

O14737

Gene name	PDCD5 (TFAR19)
Protein name	Programmed cell death protein 5
Names	TF-1 cell apoptosis-related protein 19, Protein TFAR19
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9141
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-125 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-125 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for O14737

Entry ID	Method	Resolution	Chain	Position	Source
1YYB	NMR	-	A	1-26	PDB
2CRU	NMR	-	A	9-113	PDB
2K6B	NMR	-	A	2-112	PDB
AF-O14737-F1	Predicted				AlphaFoldDB

114 variants for O14737

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs777143792 CA405167157	2	A>E		No	ClinGen ExAC TOPMed gnomAD
CA9355981 rs777143792	2	A>G		No	ClinGen ExAC TOPMed gnomAD
CA307460675 rs866745864	2	A>S		No	ClinGen Ensembl
rs777143792 CA405167155	2	A>V		No	ClinGen ExAC TOPMed gnomAD
CA405167170 rs1447704255	3	D>G		No	ClinGen TOPMed
rs759995661 CA9355982	3	D>N		No	ClinGen ExAC gnomAD
CA9355984 rs775031475	4	E>*		No	ClinGen ExAC gnomAD
rs867400032 CA307460724	4	E>D		No	ClinGen Ensembl
CA405167191 rs1351370077	4	E>G		No	ClinGen gnomAD
CA405167182 rs775031475	4	E>K		No	ClinGen ExAC gnomAD
CA9355985 rs762357474	5	E>V		No	ClinGen ExAC gnomAD
CA9355986 rs370449362	6	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA307460740 rs370449362	6	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA405167238 rs1344025213	7	E>G		No	ClinGen TOPMed gnomAD
CA307460763 rs866908210	8	A>E		No	ClinGen TOPMed
rs761684487 CA307460758	8	A>S		No	ClinGen ExAC TOPMed gnomAD
rs761684487 CA9355988	8	A>T		No	ClinGen ExAC TOPMed gnomAD
rs866908210 CA405167258	8	A>V		No	ClinGen TOPMed
CA405167278 rs1462842013	10	R>G		No	ClinGen gnomAD
TCGA novel	12	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405167322 rs1184244485	12	Q>P		No	ClinGen gnomAD
CA405167378 rs756164730	15	A>D		No	ClinGen ExAC TOPMed gnomAD
CA9355990 rs750421787	15	A>S		No	ClinGen ExAC gnomAD
rs756164730 CA9355991	15	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
RCV000973598 rs75015964 CA9355992	16	E>K		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1326539036 CA405167405	17	L>M		No	ClinGen TOPMed
CA9355995 rs374870227	22	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA9356027 rs770079518	23	D>Y		No	ClinGen ExAC gnomAD
rs749713067 CA9356029	24	P>L		No	ClinGen ExAC gnomAD
rs376281754 CA9356028	24	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9356030 rs200484934	27	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs377327115 CA307461999	28	A>D		No	ClinGen Ensembl
CA405167711 rs1442207675	29	Q>*		No	ClinGen gnomAD
CA9356033 rs771914398	29	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1385734072 CA405167722	30	Q>E		No	ClinGen TOPMed gnomAD
rs577624999 CA9356034	31	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA9356035 rs760558463	32	A>T		No	ClinGen ExAC TOPMed gnomAD
CA405167766 rs766225835	33	K>M		No	ClinGen ExAC TOPMed gnomAD
CA9356036 rs766225835	33	K>R		No	ClinGen ExAC TOPMed gnomAD
rs776661606 CA9356037	34	H>Y		No	ClinGen ExAC gnomAD
rs139511423 CA9356060	36	E>K		No	ClinGen ESP ExAC gnomAD
TCGA novel	38	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA307463806 rs145038000	39	M>I		No	ClinGen ESP TOPMed
CA9356062 rs756372501	39	M>V		No	ClinGen ExAC gnomAD
rs1470487930 CA405168527	41	N>D		No	ClinGen gnomAD
CA9356063 rs766606242	47	V>A		No	ClinGen ExAC gnomAD
CA9356065 rs754217896	49	D>A		No	ClinGen ExAC TOPMed gnomAD
CA9356064 rs754217896	49	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1335676782 CA405168744	50	Q>H		No	ClinGen TOPMed
CA9356066 rs142226357	51	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9356067 rs142226357	51	S>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1326959327 CA405168774	52	A>T		No	ClinGen gnomAD
CA9356070 rs201933073	53	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA9356069 rs147553739	53	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA405169282 rs1344014525	56	L>I		No	ClinGen gnomAD
rs1222901057 CA405169473	57	S>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9356091 rs769513977	58	N>S		No	ClinGen ExAC gnomAD
rs1461276939 CA405169549	60	A>V		No	ClinGen TOPMed
CA405169571 rs749029188	62	V>I		No	ClinGen ExAC gnomAD
rs749029188 CA9356093	62	V>L		No	ClinGen ExAC gnomAD
TCGA novel	65	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1161104656 CA405169729	68	K>T		No	ClinGen TOPMed
rs768589248 CA9356094	69	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1187429109 CA405169778	70	V>A		No	ClinGen TOPMed
rs1373282151 CA405169770	70	V>L		No	ClinGen TOPMed
CA9356095 rs774271796	71	E>Q		No	ClinGen ExAC gnomAD
CA307464602 rs568323156	72	N>H		No	ClinGen 1000Genomes
rs534083788 CA307464603	72	N>T		No	ClinGen 1000Genomes
CA405169872 rs1247536585	74	L>I		No	ClinGen gnomAD
rs771024728 CA405169914	75	I>K		No	ClinGen ExAC TOPMed gnomAD
CA9356097 rs771024728	75	I>T		No	ClinGen ExAC TOPMed gnomAD
rs776761235 CA9356098	76	Q>*		No	ClinGen ExAC gnomAD
CA9356099 rs151218453	76	Q>R		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA405170005 rs1291954396	79	R>G		No	ClinGen TOPMed gnomAD
rs1384681054 CA405170019	79	R>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA405170032 rs1287540837	80	Y>C		No	ClinGen TOPMed
rs1340372783 CA405170145	85	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1433446482 CA405171803	87	V>I		No	ClinGen gnomAD
CA307465647 rs1055990262	88	S>L		No	ClinGen TOPMed
CA9356141 rs775902452	88	S>P		No	ClinGen ExAC gnomAD
CA9356142 rs749488733	90	Q>*		No	ClinGen ExAC gnomAD
rs1342880778 CA405171913	90	Q>L		No	ClinGen TOPMed
rs1342880778 CA405171909	90	Q>R		No	ClinGen TOPMed
CA9356143 rs768956632	91	G>S		No	ClinGen ExAC gnomAD
rs541378079 CA307465684	92	L>I		No	ClinGen gnomAD
CA307465696 rs766167304	93	I>T		No	ClinGen Ensembl
rs946904915 CA307465701	95	I>V		No	ClinGen TOPMed
CA405172064 rs1364949525	96	L>H		No	ClinGen gnomAD
TCGA novel	97	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1043856377 CA405172082	97	K>E		No	ClinGen TOPMed gnomAD
rs1043856377 CA307465703	97	K>Q		No	ClinGen TOPMed gnomAD
rs1373819281	99	V>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405172150 rs1389590130	100	S>G		No	ClinGen TOPMed
CA405172210 rs1347573613	101	Q>R		No	ClinGen gnomAD
rs1226492566 CA405172236	102	Q>R		No	ClinGen gnomAD
CA9356144 rs774797370	103	T>I		No	ClinGen ExAC gnomAD
CA9356145 rs371635048	104	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs371635048 CA405172300	104	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA307465721 rs4723	104	E>K		No	ClinGen Ensembl
CA9356147 rs768068425	105	K>N		No	ClinGen ExAC
rs1305805009 CA405172365	105	K>R		No	ClinGen gnomAD
rs1447628058 CA405172429	106	T>I		No	ClinGen TOPMed
CA405172447 rs1275956683	107	T>A		No	ClinGen gnomAD
rs760230651 CA9356149	108	T>A		No	ClinGen ExAC gnomAD
rs765847413 CA9356150	108	T>I		No	ClinGen ExAC gnomAD
rs1489041596 CA405172559	110	K>T		No	ClinGen gnomAD
CA405173356 rs1156681047	111	F>L		No	ClinGen gnomAD
rs752278730 CA9356173	114	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs935464619 CA307466003	117	M>T		No	ClinGen TOPMed
CA405173646 rs1471828455	119	S>F		No	ClinGen TOPMed
rs1599723932 CA405173752	121	E>D		No	ClinGen Ensembl
rs1464833542 CA405173745	121	E>G		No	ClinGen TOPMed
CA405173827 rs1405408090	124	D>G		No	ClinGen gnomAD
rs1317766226 CA405173872	126	Y>G		No	ClinGen gnomAD

No associated diseases with O14737

No regional properties for O14737

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O14737

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name	Definition
acetyltransferase activator activity	Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule.
beta-tubulin binding	Binding to the microtubule constituent protein beta-tubulin.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
heparin binding	Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

9 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cellular response to transforming growth factor beta stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of chaperone-mediated protein folding	Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated protein folding.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of protein insertion into mitochondrial outer membrane	Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial outer membrane.
positive regulation of release of cytochrome c from mitochondria	Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2HJH9	PDCD5	Programmed cell death protein 5	Bos taurus (Bovine)	PR
P56812	Pdcd5	Programmed cell death protein 5	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MADEELEALR	RQRLAELQAK	HGDPGDAAQQ	EAKHREAEMR	NSILAQVLDQ	SARARLSNLA
70	80	90	100	110	120
LVKPEKTKAV	ENYLIQMARY	GQLSEKVSEQ	GLIEILKKVS	QQTEKTTTVK	FNRRKVMDSD

EDDDY