O14423
Gene name |
cbh1 (cbh, SPAC9E9.10c) |
Protein name |
CENP-B homolog protein 1 |
Names |
CBHP-1 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC9E9.10c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O14423
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O14423-F1 | Predicted | AlphaFoldDB |
3 variants for O14423
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_4459643_C_T | 376 | S>N | No | Jeffares_SNPs | |
| I_4459613_C_T | 386 | R>Q | No | Jeffares_SNPs | |
| I_4459568_A_T | 401 | M>K | No | Jeffares_SNPs |
No associated diseases with O14423
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| condensed chromosome, centromeric region | The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. |
| mitotic spindle | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| centromeric DNA binding | Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPPIRQAVSL | AEKKAIRDYY | NQSAHRIPQK | EVTEWFRKTY | NKDLSQSTIS | EILSPKYSYL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDGSVRLGDI | KKIRAPKFPL | LDNAVYEWLQ | QREVEGLPIS | GDMIKQAATR | FWSKIPAYAS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPLPDFSNGW | LDKFRRRHYI | QQSAVNQALE | SIKFEVFREY | PVHIQEFIRP | YAQKDIFCVG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTSLFWKLTP | NKQNLDYQEI | QGMKRGKAKV | SLIMCCNADG | SERLPLWIVG | YAQNPRSFEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CGIFPKSMNF | EWKWNGRASI | SPIIMEEWLR | WFDTRMQGRK | VLLMLESNDT | YQFGVESVRR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FKGGFQNTSV | FRIPEKTLDI | KSPFEQGIVD | TFKANYRRYW | LQYSLNQINI | LRDPLKAVNV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LKAIRWMLWS | WNFGVSEKTI | QASFLRSGLL | GPHSEAEGQG | MESYQKAIME | IGNLISSKGS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EAVKQINEYI | RPSEEDETKL | HQDAVDTVAA | EFLEERRFES | DEEEDVEPQI | SNVEAAMAFE |
| 490 | 500 | 510 | |||
| VLIKYFEQHE | NGDPSFVLDL | YRRQRVIAPN | NLIA |