O14308
Gene name |
swc4 (SPAC9G1.13c) |
Protein name |
SWR1-complex protein 4 |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC9G1.13c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O14308
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O14308-F1 | Predicted | AlphaFoldDB |
2 variants for O14308
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_1996613_T_C | 24 | K>R | No | Jeffares_SNPs | |
| I_1995272_T_C | 417 | K>R | No | Jeffares_SNPs |
No associated diseases with O14308
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| NuA4 histone acetyltransferase complex | A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Swr1 complex | A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| transcription corepressor activity | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| histone exchange | The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. |
| histone H2A acetylation | The modification of histone H2A by the addition of an acetyl group. |
| histone H4 acetylation | The modification of histone H4 by the addition of an acetyl group. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| nucleosome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTSADIRDVF | ELPPPEIGNK | QKSKTPTERR | PEGISRELYS | LLGENSAPLA | IYQKKFKEKP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KVSHKAKNWV | RQPFSISSRK | DDFTLHHWVL | KSEVDSEASY | KFEKFNVPLF | IIDYTDEEYQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NYLKDEDWNK | DETDYLFRLC | KDYDLRFFVI | ADRYDNEKYK | KHRTLEDLKD | RFYSVSRKIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LARNPINSMT | AAQSSLLNTM | EYNKEQEVIR | KKYLIGLASR | TPEEVAEEEA | LFIELKRIET |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SQAKLLSDRD | EVLRLLDEQK | GDGGIHEYHT | SAGMSSLIQD | MINSQRTKNK | VEEAIVSSSA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PSSGVSSVLN | TPTRPHALST | PRIRYGPQPT | DPQFGITWHE | KLHPGTFVRS | QKIPAIKASL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SQRVSSVMTE | LGVSSRLIMP | TAKNFEKFVE | LQNSIVSLLE | LKRKVDRLSQ | ETEIQDKLSR |
| 430 | |||||
| KRSASPDGSE | SKKHISQ |