O14258

PR
Gene name
ace2 (SPAC6G10.12c)
Protein name
Metallothionein expression activator
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC6G10.12c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O14258

Entry ID Method Resolution Chain Position Source
AF-O14258-F1 Predicted AlphaFoldDB

13 variants for O14258

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3240657_G_A 104 P>L No Jeffares_SNPs
I_3240528_G_C 147 S>C No Jeffares_SNPs
I_3240521_C_G 149 Q>H No Jeffares_SNPs
I_3240436_C_T 178 D>N No Jeffares_SNPs
I_3240352_T_C 206 T>A No Jeffares_SNPs
I_3240211_A_C 253 S>A No Jeffares_SNPs
I_3240039_T_C 310 D>G No Jeffares_SNPs
I_3240000_T_C 323 E>G No Jeffares_SNPs
I_3239956_C_T 338 G>R No Jeffares_SNPs
I_3239898_C_T 357 S>N No Jeffares_SNPs
I_3239895_G_A 358 A>V No Jeffares_SNPs
I_3239853_C_A 372 C>F No Jeffares_SNPs
I_3239778_G_A 397 T>I No Jeffares_SNPs

No associated diseases with O14258

No regional properties for O14258

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O14258

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion binding Binding to a metal ion.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSLSYLSSSS QKSFESFRQE ESPACNHSYQ RDYETFGDSK HTSFSSFAPF ENEVSLNQAV
70 80 90 100 110 120
IPSPPSHLQN FQDQFDYSSV LKTPFNPLLE ANSAYFLSNQ ISLPDSHSYA SSFDASLSPP
130 140 150 160 170 180
SSPLTCVSQI HTEQNFNNND AFSLTNSQQA FSEIGYDASN WIDELDSQQQ VLSFPEFDIP
190 200 210 220 230 240
EIKTETCSNK DHLENFDYLS SSIPETSGPA SSVLPSSSQL ESFNEFMFLP SSPPGLDEIN
250 260 270 280 290 300
GAPSFEELNF QISQPSPAHP VDLSSPETAP NISPVSPFAQ LVKLEPTSPQ KPSFALDSSF
310 320 330 340 350 360
SHLDVCRHTD NQKAFAKLSS PAEYVSEFEK FSSVCDHGLD ISNANINNTL TQQFALSAPY
370 380 390 400 410 420
ESCIVTKKPE PCITVKEEEQ LAPKIESADL SITPQVTEHD SKPPVRISYD HRCKTRKQST
430 440 450 460 470 480
RICRIPPETM ASLYCGPEAD GKYVCLYNGC NKRIARKYNV ESHIQTHLSD RPYRCDLCKA
490 500 510 520 530
GFVRHHDLKR HLRIHENGRP YVCECLKRFN RLDALNRHKQ RNICVGGVDR RQH