O14251

PR
Gene name
trs120 (SPAC6G10.05c)
Protein name
Transport protein particle subunit trs120
Names
TRAPP subunit trs120
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC6G10.05c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

167-269 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O14251

Entry ID Method Resolution Chain Position Source
AF-O14251-F1 Predicted AlphaFoldDB

24 variants for O14251

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3225796_G_A 136 P>L No Jeffares_SNPs
I_3225647_C_T 186 A>T No Jeffares_SNPs
I_3225575_C_A 210 A>S No Jeffares_SNPs
I_3225545_G_A 220 R>C No Jeffares_SNPs
I_3225511_G_A 231 S>L No Jeffares_SNPs
I_3225478_T_C 242 K>R No Jeffares_SNPs
I_3225226_G_A 326 A>V No Jeffares_SNPs
I_3225215_G_A 330 L>F No Jeffares_SNPs
I_3225206_C_T 333 D>N No Jeffares_SNPs
I_3224908_G_A 432 S>L No Jeffares_SNPs
I_3224731_G_A 491 S>L No Jeffares_SNPs
I_3224246_G_T 653 Q>K No Jeffares_SNPs
I_3224050_G_A 718 T>M No Jeffares_SNPs
I_3223996_T_A 736 E>V No Jeffares_SNPs
I_3223946_G_A 753 H>Y No Jeffares_SNPs
I_3223781_G_C 808 L>V No Jeffares_SNPs
I_3223605_T_G 866 E>D No Jeffares_SNPs
I_3223241_C_T 988 V>I No Jeffares_SNPs
I_3222762_G_A 1126 R>C No Jeffares_SNPs
I_3222754_T_G 1128 K>N No Jeffares_SNPs
I_3222659_T_G 1160 N>T No Jeffares_SNPs
I_3222642_C_A 1166 V>L No Jeffares_SNPs
I_3222588_G_A 1184 R>C No Jeffares_SNPs
I_3222581_A_G 1186 F>S No Jeffares_SNPs

No associated diseases with O14251

No regional properties for O14251

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O14251

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus, cis-Golgi network
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.
cleavage furrow The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
growing cell tip The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs.
trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
TRAPPII protein complex A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
Golgi to plasma membrane transport The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
intra-Golgi vesicle-mediated transport The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
membrane addition at site of mitotic cytokinesis A mitotic cell cycle process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEFDFFSFVA PSRVQSLVLP FGRVRRKSFS SYLQLLRRVS HIQLSDVPVA TATRKSSSFN
70 80 90 100 110 120
PLAFPLGRLV YNFLTSLDDQ QALLEEFEYF RRVFVLIGIV DGSEEQEVEQ LCSTLDVWRR
130 140 150 160 170 180
RIPHALVAKC IVFNCPEDKE NIFNAPNIII GPRSDFSINS VMRSILCDIT AELLEGFSSL
190 200 210 220 230 240
EFSIHARSVI LSPITDMPHL APLQRKNSNA SIHSLGSSSR PTLTRTPSIT SRSVNSVTER
250 260 270 280 290 300
SKSLSKGRIE NQFGQLYLLA GRVPNALKHF STAIALSKAT GDFLWQGLSL ELFTVCLVIM
310 320 330 340 350 360
AHLHVDVQIP PNILSMFPSY NDRLNAFGPL KFDALLNFIT EMRNVVDQLY QKSTLQPNDA
370 380 390 400 410 420
VPGLCFSESI LRYAHLLTVV YSCKGFNDNA LDHIIAQAPI RPVKKATTYV PNKATICQWI
430 440 450 460 470 480
MRAQGQHLNS LSIRERCRIY GAMANMLGSI GFSRLRVKML RELVASLTPV LLETRRQNAS
490 500 510 520 530 540
KNGIHPEVIA SHTAQSFKST HYCNILPLIS EICQEYGLLK TDGSLLNPEL TKWGWSNLQF
550 560 570 580 590 600
DVLNELISLC DSLSDYRSIL LLISLFFLTS VQTASSSQQI SMFKAFRKTY LFASNAGIHI
610 620 630 640 650 660
NAPYWDPFMI TDLKFIGSSE NAELIHQRLR NGLPKSIEKG PFIYNPFNRR QDQNQSKSVL
670 680 690 700 710 720
VVDEQVAFSI YFRNPLSVSV EVQDVHLETK GVSAKCSHST FTMRPLSIER TTLTVTPTET
730 740 750 760 770 780
GELHIVGCRV KVFGCEPILQ YVYEAKDKHK SLHVYLEKSK DVNAELRSLD TIDHLWTYFP
790 800 810 820 830 840
FKKDLKTKSF DCIVIASQPK LSLAFQNLTS GKFNFAEYET GELVYVIENT SFVEASHISV
850 860 870 880 890 900
LFEDSSSKAF EQAIADKSIT ADRLYELQFE EFNLPTFTVE SSQPFSLSPG ERREIHIKIR
910 920 930 940 950 960
AKPNSQEGLI LFESSVHKPE DTEFYVRRLR IPVSLNISKR VDLKQWSAFM DTEGDPSYCL
970 980 990 1000 1010 1020
VLLNFYNHFS EPLFVTVKTA STDESRSVLI KPKADNVILF RLKRFIMSSE EINLDIPNLS
1030 1040 1050 1060 1070 1080
TKQFVLSSGF KKSIEDSYTM KKRFWIKEYF LKEVQASWKT DDNLHHGEIY LRNHILSDEM
1090 1100 1110 1120 1130 1140
ANNLSILPIR IQAWVSYDSE KVTTVCPREP FKLVLEFFGH ADTNMRYKIS WTQLNTQANT
1150 1160 1170 1180 1190 1200
SSFNGLILDG PEEDIVCFNN SKCHVVIERN MFAYTTGMYN IFVRIFNEEL QLLSQPVDLD
EPILLIVDAK