O14234

PR
Gene name
cch1 (SPAC6F6.01)
Protein name
Calcium-channel protein cch1
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC6F6.01
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-96 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O14234

Entry ID Method Resolution Chain Position Source
AF-O14234-F1 Predicted AlphaFoldDB

22 variants for O14234

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2727250_C_T 178 L>F No Jeffares_SNPs
I_2727268_C_T 184 H>Y No Jeffares_SNPs
I_2727449_G_A 244 G>D No Jeffares_SNPs
I_2727613_A_G 299 M>V No Jeffares_SNPs
I_2727914_A_G 399 N>S No Jeffares_SNPs
I_2728051_G_A 445 D>N No Jeffares_SNPs
I_2728583_G_T 622 C>F No Jeffares_SNPs
I_2729417_C_T 900 P>L No Jeffares_SNPs
I_2729650_G_A 978 A>T No Jeffares_SNPs
I_2729714_T_C 999 I>T No Jeffares_SNPs
I_2729803_A_G 1029 I>V No Jeffares_SNPs
I_2729828_G_A 1037 S>N No Jeffares_SNPs
I_2729837_T_C 1040 L>S No Jeffares_SNPs
I_2729846_G_A 1043 R>Q No Jeffares_SNPs
I_2729863_A_G 1049 K>E No Jeffares_SNPs
I_2729926_G_A 1070 A>T No Jeffares_SNPs
I_2730056_T_C 1113 L>S No Jeffares_SNPs
I_2730455_A_G 1246 K>R No Jeffares_SNPs
I_2730720_G_A 1334 M>I No Jeffares_SNPs
I_2730719_T_G 1334 M>R No Jeffares_SNPs
I_2731135_A_G 1473 N>D No Jeffares_SNPs
I_2731650_A_G 1644 I>M No Jeffares_SNPs

No associated diseases with O14234

2 regional properties for O14234

Type Name Position InterPro Accession
domain ResB-like domain 30 - 292 IPR007816-1
domain ResB-like domain 307 - 444 IPR007816-2

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
voltage-gated calcium channel complex A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.

2 GO annotations of molecular function

Name Definition
calcium channel activity Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
high voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.

2 GO annotations of biological process

Name Definition
calcium ion import across plasma membrane The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSSSNSDPS SSPDNTDFIP LKDNPKDTSS YINKKNPFVN DSFDSHDDSY LDNVNPFEYN
70 80 90 100 110 120
VADDEDTISM TSDGVEFHNL GITETVDEQD KILSELQLAY PTVSRYSETL DKGLLNGDKT
130 140 150 160 170 180
TKGDYTSLRR FRKPFLFDKL SPYFTHFFSE IYAAVLRVVG PPRANETPGR NLPFSPILRQ
190 200 210 220 230 240
IYNHPLYNIF IFVVIVLHAV LLMIRSDDPH DKSQTIDYLI IVIGILYTLE MLLKIYLFGF
250 260 270 280 290 300
LYDGSSSFYD FINSYTKKTP RTMSYLRHSW NRVDFVAIVA LWISVIGKKQ QGIFRLFSMI
310 320 330 340 350 360
ACLRLTRLLN ITRKTETILK SLKESSTPLV QVVSFNAFFG VMIAILGVQF FKASLNRQCV
370 380 390 400 410 420
WLGDYGDQYL PTGQFCGGHW ENGIKRAYLD KNGFPSNVNP RGFICAEKSV CRVVENPYSN
430 440 450 460 470 480
TVSFDNFFNS LELIFVIMSS NGFTDIMYDI MDAEYFVSCL LFIISAYFLT LWLMSLVIAV
490 500 510 520 530 540
VTSSFIDLQH SGKNQKEQKS VDKHLIRNKL CEKYLFYSNF IWISFIVAQF VTLCTQTYDQ
550 560 570 580 590 600
TSSTANRYLI FYACVDFLLA AEVILRFFAY LPDYRLFFRR YTNLVDIVLA VLNLVTLLPS
610 620 630 640 650 660
IRKNPVAFGW LSIFAIARIY RCILLIPYTR KIAKLLFSNF KQLLNLMLFL VIVLFIASLC
670 680 690 700 710 720
AVRLFQDLPN DGDSDDDAIS FATTYESFLY MYQILTSENW TDVMFAIQAR LAHLHLSWIP
730 740 750 760 770 780
GAFFTLWFLF SNNVVLSMFI AVIQVNFAPS ESDLKMEQLK MYLARLLRNY NPFQASLTLN
790 800 810 820 830 840
ALIKRNGSRK GKTVDESHYE WLYEDNIIKG FLRVTNIPPK EPLKPSLDTS PELSKYSLAK
850 860 870 880 890 900
LSNNFKRFVM RDDPFSQAYF KRVIGIRWEK DMNLKTAAKD MQAAKAFVRI KQTEFLKNHP
910 920 930 940 950 960
KYNDVFWVIK PSNRIRRFCQ RLVMPGVNER YGGVEPYQWV YRVIQVFIYA CILTAVIIEC
970 980 990 1000 1010 1020
IATPIYERDH LLNDKQHAWF VWTEVAFATI FTIEAAIKII ADGFCITPNA YLRSTWNCID
1030 1040 1050 1060 1070 1080
FFVLVTLWIN LYAVLTSHAL LSRAFRAFKA LRVLRLINLT QTSQRMFHDA LISGFFKIFS
1090 1100 1110 1120 1130 1140
AAVVSATLLI PFALWAKNVF GGLLYSCNDD NVLSASQCVL EYASTPNNWE VWAPRVWSNP
1150 1160 1170 1180 1190 1200
PDYDFDRFPH ALLALFEIAS IEGWVDIMRS VMDITGFNNQ PQTNASSGNA MFFVLFNLVS
1210 1220 1230 1240 1250 1260
MIYILTLFIA IIISNYAERT GSAFFTAEQR AWLELRRKIK SMRPSKRPAI RPLGLRGLCY
1270 1280 1290 1300 1310 1320
DFAVQKHGIW RRTFTGLYIV HLLFLLTIFY PCPIAYTYVR NSIFLILSIC YTINICVKVY
1330 1340 1350 1360 1370 1380
GLSFYYFFHS FWNMFDVVVT LGSLTCNIAI LAKFENRSLT LLQTTLLVLV TVHLIPKFDN
1390 1400 1410 1420 1430 1440
FDQLSKTVVA SLPSIFSLIA TWIVLYITFA IAFNQIFGLT KLGLNGGPNK NFRSIRNALV
1450 1460 1470 1480 1490 1500
LLFTMTFGEG WNDVMHDYTI SYPNCVNGDD FYNSDCGNKP WAYGLFIAWN IISMYIFVNM
1510 1520 1530 1540 1550 1560
FITVVFDNFS YIHTKSSSFT NLQRNDFRQF KDSWAPFDPM VTGYIPKRNA VKFVLSLRGV
1570 1580 1590 1600 1610 1620
YDFRIYRDEH TLRSIISKVQ SKTGQQSVPM LENPLMGSEI NLEALDQIID TIDVNVVKER
1630 1640 1650 1660 1670 1680
RNVLNSLCTE IMTLPGNVIS FSNILMLVVL HKIVDHREAF PISDYIRRAY VLSELEKSIR
1690 1700 1710 1720 1730 1740
MEKLLGLVET SIIRKTFLQH MEEKKKALEN PFILLSEVSE ILPETPIQEV LRQHNADPEQ
1750 1760 1770 1780 1790 1800
LLMSTRTPSV SDRSFSIVES TVPTIASGEG DDNHSVEDHL KVPTDNEPRR SPSLKEVLLR
1810 1820 1830 1840 1850
GSHSLHSNND RTSFDIEAGF GTAESDFQFG GATEDINRIA DRIDDYLDRD SFKG