O14233

PR
Gene name
rna14 (SPAC6F12.17)
Protein name
mRNA 3'-end-processing protein rna14
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC6F12.17
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O14233

Entry ID Method Resolution Chain Position Source
AF-O14233-F1 Predicted AlphaFoldDB

9 variants for O14233

Variant ID(s) Position Change Description Diseaes Association Provenance
I_1349203_A_G 142 T>A No Jeffares_SNPs
I_1349362_C_G 195 P>A No Jeffares_SNPs
I_1349872_A_G 365 N>D No Jeffares_SNPs
I_1350074_A_G 432 K>R No Jeffares_SNPs
I_1350302_T_C 508 V>A No Jeffares_SNPs
I_1350323_A_C 515 Y>S No Jeffares_SNPs
I_1350484_C_G 569 Q>E No Jeffares_SNPs
I_1350628_G_A 617 G>R No Jeffares_SNPs
I_1350755_C_T 659 A>V No Jeffares_SNPs

No associated diseases with O14233

10 regional properties for O14233

Type Name Position InterPro Accession
repeat HAT (Half-A-TPR) repeat 85 - 117 IPR003107-1
repeat HAT (Half-A-TPR) repeat 119 - 150 IPR003107-2
repeat HAT (Half-A-TPR) repeat 158 - 193 IPR003107-3
repeat HAT (Half-A-TPR) repeat 204 - 237 IPR003107-4
repeat HAT (Half-A-TPR) repeat 312 - 344 IPR003107-5
repeat HAT (Half-A-TPR) repeat 346 - 378 IPR003107-6
repeat HAT (Half-A-TPR) repeat 454 - 486 IPR003107-7
repeat HAT (Half-A-TPR) repeat 489 - 521 IPR003107-8
repeat HAT (Half-A-TPR) repeat 523 - 557 IPR003107-9
domain Suppressor of forked 440 - 716 IPR008847

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Nucleus and/or cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
mRNA cleavage and polyadenylation specificity factor complex A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

4 GO annotations of biological process

Name Definition
mRNA 3'-end processing Any process involved in forming the mature 3' end of an mRNA molecule.
mRNA cleavage Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.
mRNA polyadenylation The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNSDDNVEAD ASSNIIKDSP KIKEQENTST VNESDVLATS TTASSGVKRK RLPNDLVGQL
70 80 90 100 110 120
RDKIQENPND ISSWYALVEE YGSKGKHEEL RETYEQMLRP FPYVPRVWVD YISSELAFND
130 140 150 160 170 180
FHAVELLFSR CLVKVLSVDL WTLYLSYIRR INPDGEGQSR STITQAYEFV INTIGVDILS
190 200 210 220 230 240
GPIWSEFVDF LRSGPANSTW EQQQKLDHVR RIYQRAITTP IHNIEKLWRD YDAFENSVNR
250 260 270 280 290 300
ATARKFVAEK SPVYMAARAA MRELSNLTEG LRVYDFTFER KYTKVERIAY SRWMNWIKWE
310 320 330 340 350 360
QSDPLDLQHG TMLQNRIAYA FEQAMLYVPL CPQIWLDGFS YFLSISDEQR ALQTIRRGMR
370 380 390 400 410 420
YCPSNFVLHV RYAEHEEANN RTSEIRSTYE SLIAALAREI SQLDSKASSS SESSTDGNPQ
430 440 450 460 470 480
EKKLPEHLVK RKSRLVRQYS LAWCCLINAI RRTEGVKAAR AIFTKARKAP YQSHEIYIAS
490 500 510 520 530 540
AMMEHHCSRD PVIASRIFEL GMRHFGDVPA YVYKYLSYLI AINDETNARA LFEKAIPRIA
550 560 570 580 590 600
ADEAKPIYQK WLDYESNYGD LNAAIALSQR MAVVYPQEST QAIFLSRYGL KDDAEEEERE
610 620 630 640 650 660
TKEAEKIREL SVRLNGGNGF PGHVHNNRED DEVSIASTSS KSNVEMEDTR LLPASLELAN
670 680 690 700 710 720
TQGASNPPTS ALPTVPVPLP SIITEFLDEL PAPQVITGPR IQPTKLIDHI IKSDIPFIRL
730
RNANAHLKRA RFN