O14227

PR
Gene name
rdp1 (csp7, rdr1, SPAC6F12.09)
Protein name
RNA-dependent RNA polymerase 1
Names
Protein rdp1
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-83 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O14227

Entry ID Method Resolution Chain Position Source
AF-O14227-F1 Predicted AlphaFoldDB

20 variants for O14227

Variant ID(s) Position Change Description Diseaes Association Provenance
I_1325400_G_T 50 A>S No Jeffares_SNPs
I_1325454_G_A 68 G>R No Jeffares_SNPs
I_1325463_A_C 71 I>L No Jeffares_SNPs
I_1325545_A_G 98 H>R No Jeffares_SNPs
I_1325753_T_A 167 N>K No Jeffares_SNPs
I_1325771_G_T 173 Q>H No Jeffares_SNPs
I_1326156_C_T 302 P>S No Jeffares_SNPs
I_1326174_A_G 308 I>V No Jeffares_SNPs
I_1326228_C_G 326 L>V No Jeffares_SNPs
I_1326250_A_T 333 E>V No Jeffares_SNPs
I_1326276_C_A 342 L>I No Jeffares_SNPs
I_1326652_T_A 467 V>D No Jeffares_SNPs
I_1326846_A_G 532 I>V No Jeffares_SNPs
I_1326928_C_T 559 A>V No Jeffares_SNPs
I_1327476_G_A 742 D>N No Jeffares_SNPs
I_1327893_A_T 881 I>L No Jeffares_SNPs
I_1328194_A_G 981 N>S No Jeffares_SNPs
I_1328389_G_A 1046 S>N No Jeffares_SNPs
I_1328448_C_T 1066 L>F No Jeffares_SNPs
I_1328529_G_A 1093 A>T No Jeffares_SNPs

No associated diseases with O14227

No regional properties for O14227

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O14227

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Chromosome, telomere
  • Chromosome, centromere
  • Associates with telomeric and mating-type region heterochromatin
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
chromosome, subtelomeric region A region of the chromosome, adjacent to the telomere (on the centromeric side) that contains repetitive DNA and sometimes genes. This region is usually heterochromatin.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mating-type region heterochromatin Heterochromatic regions of the chromosome found at silenced mating-type loci.
nuclear RNA-directed RNA polymerase complex A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
pericentric heterochromatin Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3).

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

7 GO annotations of biological process

Name Definition
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
co-transcriptional gene silencing by RNA interference machinery A process in which the RNAi machinery mediates the degradation of nascent transcripts in association with chromatin.
G1 to G0 transition A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence.
heterochromatin assembly by small RNA A heterochromatin formation-based gene silencing process mediated by a small RNA molecule that occur before the beginnning of trancription.
negative regulation of G0 to G1 transition A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.
pericentric heterochromatin assembly The compaction of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by methylation of histone H3K9, into heterochromatin, resulting in the repression of transcription at pericentric DNA.
siRNA processing A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVSLNDFIS VKLKRYSRES PWERLRVPYR NKKQKKWASV HNNEAQLHSA NKRNDNCLIQ
70 80 90 100 110 120
RSSTWRLGDM ITLVIKDIPV TWLSNEGGKL YNLWEPLHDY GTIEFMKINE PLNGQTSTTA
130 140 150 160 170 180
IVQFAPPPKV PFWEPNGKIN VKGVDLAVQI DITAHRSHIS RQVFSKNSFR SDQLVKIPLS
190 200 210 220 230 240
SFKLGQVYDE RIVPLFGVDC GITVTESNLL VYFNFKKLCV LFDASFDKQI ETFRLDFDFH
250 260 270 280 290 300
SIIGDVGTDY YDDHISLVFR FRFSPLIFRK SKNATESRVQ TFWTASHLWR RHYDILPFNV
310 320 330 340 350 360
SPTTASPIEL LNCHNAPIGR CNVLVLSFSI RDESDKDDIA FLLHNLEKFN LKSQLDKVVF
370 380 390 400 410 420
HLVPDYKHRC SLINDKEIEE EIAYLLQACL SKNLLSEIDL PIILANLKKL SKERAKKFLR
430 440 450 460 470 480
LILTSKTALI NPSELDFTKS FVFYDLSSAS SIHIKKLYVT PTTLRIVEDS LEAGNRVIRN
490 500 510 520 530 540
FKDFANRFMR VQITDEYYKQ KIRGGSDGFR NEKLYSRIQQ LLTYGIKVGN QIYEFLAFGN
550 560 570 580 590 600
SQLREHGAYF FASGSDLNAK QIREWMGDFS EINSVSKYAA RMGQCFSTTK EINRFCVDIS
610 620 630 640 650 660
LQDDIVRNNH CFTDGVGMAS LSVIRRLSLE VKNHDMFPSA FQFRMGGYKG VLSLAPPTKL
670 680 690 700 710 720
EYHQGNLVFP RRSQDKFKSF HSTLEVIKIS RFSNAHLNMQ LITLLEGLGV EKTVFLELTR
730 740 750 760 770 780
SQLSKMNESI NSKQKSILML RDNVDEYHST LIIADFIQAG FLERDDAFTE NLLNLYYEWV
790 800 810 820 830 840
LRLIKEKQKV SVPKGAYLLG VADETGTLKG HYDDAVLSVP EIFIQITDTS TSFGSYSTGK
850 860 870 880 890 900
LKTRVIVGLC IVARNPSLHP GDVRVCKAVR CDELMHLKNV IVFPTTGDRS IPAMCSGGDL
910 920 930 940 950 960
DGDEYTVIWD QRLLPKIVNY PPLLESSPKK SIDFLEGKPL IDSVKEFFVN YIKYDSLGLI
970 980 990 1000 1010 1020
SNAWKAWAHD HDNNPEGIFG NVCLELAEMH SKAVDFAKSG VACKMQAKYH PKRYPDFMQK
1030 1040 1050 1060 1070 1080
TKTRSFRSET AVGKIFRYAA RFQRESGRPA TYNPIMNTVY DPCMKLPRFK TEYLNVAEEV
1090 1100 1110 1120 1130 1140
KKHYDNDLRS IMARFDISTE YEVYTAFILF KDDLAKTVNE YGLREEVSFQ FDLLKKKYTQ
1150 1160 1170 1180 1190 1200
EYLEKCALSN QSAFDSSEYE ERINSAVAAT YDVTYDQRVK SVGNGTTEVL ISFPYLFSSR
1210
LCQLSRKAML TANNF