O14216
Gene name |
drc1 (sld2, SPAC6B12.11) |
Protein name |
DNA replication regulator sld2 |
Names |
DNA replication and checkpoint protein 1 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC6B12.11 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O14216
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O14216-F1 | Predicted | AlphaFoldDB |
6 variants for O14216
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_2431256_T_C | 68 | V>A | No | Jeffares_SNPs | |
| I_2431289_G_A | 79 | R>H | No | Jeffares_SNPs | |
| I_2431328_G_A | 92 | R>Q | No | Jeffares_SNPs | |
| I_2431336_T_C | 95 | Y>H | No | Jeffares_SNPs | |
| I_2431529_C_T | 159 | P>L | No | Jeffares_SNPs | |
| I_2431715_A_G | 221 | E>G | No | Jeffares_SNPs |
No associated diseases with O14216
No regional properties for O14216
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O14216 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| DNA replication preinitiation complex | A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present. |
| nuclear replication fork | The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA replication origin binding | Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication initiation | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. |
| double-strand break repair via break-induced replication | The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome. |
| mitotic DNA replication initiation | Any DNA replication initiation involved in mitotic cell cycle DNA replication. |
| mitotic DNA replication preinitiation complex assembly | Any DNA replication preinitiation complex assembly that is involved in mitotic cell cycle. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHDESRTKQI | SSIKALLKKW | EHEYVHTNNC | KPSKEDVKKQ | PEIALLYKQY | YELKRESSIT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PKKAKTKVDF | KFQTPTKQRA | ETEANESPKA | PRNDYLQVTP | KTVDKSLLGP | TPQLSRRVLN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLEDMSPIAD | SHVDQISDIK | HNTSEISSTM | IPTTPSKNPE | PVAQHTPTVL | ETPSSYRLQV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YTSPNLLRVN | APCRKSLSEM | LRELKDIEDD | YGSNEEKILQ | EFESFSSSSS | ESLVDRDISQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PMKKKIKRQN | RLVKLPPSMN | LSKSHLEGLP | EIDEDAENGI | DDNEDTTASK | DSSPFLDLQS |
| 310 | 320 | 330 | |||
| ERQNKKIMRN | GLVIGKQVSQ | NYSSYKLKKR | KFRRHRS |