O14189
Gene name |
SPAC10F6.17c |
Protein name |
Protein phosphatase 2C homolog C10F6.17c |
Names |
Pyruvate dehydrogenase (Lipoamide) phosphatase C10F6.17c |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC10F6.17c |
EC number |
3.1.3.16: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O14189
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O14189-F1 | Predicted | AlphaFoldDB |
6 variants for O14189
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_1241231_C_T | 142 | R>K | No | Jeffares_SNPs | |
| I_1241199_G_T | 153 | H>N | No | Jeffares_SNPs | |
| I_1241162_T_C | 165 | K>R | No | Jeffares_SNPs | |
| I_1240764_T_C | 298 | I>V | No | Jeffares_SNPs | |
| I_1240758_C_T | 300 | E>K | No | Jeffares_SNPs | |
| I_1240516_G_T | 380 | D>E | No | Jeffares_SNPs |
No associated diseases with O14189
1 regional properties for O14189
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PPM-type phosphatase-like domain | 75 - 439 | IPR001932 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.16 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| [pyruvate dehydrogenase (lipoamide)] phosphatase activity | Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate. |
| metal ion binding | Binding to a metal ion. |
| myosin phosphatase activity | Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| generation of precursor metabolites and energy | The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. |
| positive regulation of pyruvate dehydrogenase activity | Any process that activates or increases the frequency, rate or extent of pyruvate dehydrogenase activity. |
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNFFTSAVGS | KVFKRNNFKY | VAIAASSIGL | AAYHIRKDAI | ALDIPNSTYQ | HVSKNRVPPT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DGDGITKRLK | EFERTVTVNK | DGIFRYDFNQ | VASNDPCEDD | HVEVIDRNID | EGNWYFWGIF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DGHSGWNTSL | FLRQHLVPAV | VRELQKCTAS | YYHQNACPSS | LALDKSISEA | FAKVDHQIVH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EHVSHVFNNP | ESLQVAASLL | LPALSGSCAL | LTSYSAKSKS | LQVACTGDSR | AVLGECTPDG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SWEAIPLSRD | QTGMNPDEAS | RLEVEHPGEE | VLRNNRILGR | LMPSRAFGDA | RYKWSQEISE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RLHREYFSAS | PIPVKTPPYV | TAVPEIESIT | VNPKKHRFLI | MASDGLWDTM | SSEQAVQLVG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EWADTVLGKT | TNEKNTTQDD | KQSWSLFKKT | SKVIDDNAAT | HLIRHSLGGS | DQRISALLTL |
| 430 | 440 | ||||
| TYPISRRYRD | DITVTVIFFD | EKTL |